Decoding a Rare Case of Pleomorphic Adenoma: A Case Report and Review of the Literature.

Diagnosing palatal swellings is crucial for various reasons, mainly because these swellings can signal a range of health problems, from benign conditions to more serious diseases. Here, we have reported an interesting case of long-standing palatal swelling. Accurate diagnosis typically involves a combination of clinical examination, patient history, imaging studies, and possibly biopsy or other laboratory tests.

Nonsurgical management of large periapical lesions: case reports and review of the literature.

The objectives of this article are to report 2 cases of nonsurgical endodontic treatment for the management of periapical lesions associated with large cortical bone perforations and review the literature on the clinical efficacy of nonsurgical endodontic treatment to draw insights from published case reports. Large, cyst-like periapical lesions in 2 patients were successfully treated with combined modalities of root canal treatment, antimicrobial therapy (calcium hydroxide and triple antibiotic paste [TAP]), and mineral trioxide aggregate (MTA) obturation of the canal space. In both cases, instrumentation was extended 1 mm beyond the apical foramen to facilitate drainage through the root canal, because it was assumed that the periapical lesion could be cystic.

Novel FOXM1 inhibitor STL001 sensitizes human cancers to a broad-spectrum of cancer therapies.

Forkhead box protein M1 (FOXM1) is often overexpressed in human cancers and strongly associated with therapy resistance and less good patient survival. The chemotherapy options for patients with the most aggressive types of solid cancers remain very limited because of the acquired drug resistance, making the therapy less effective. NPM1 mutation through the inactivation of FOXM1 via FOXM1 relocalization to the cytoplasm confers more favorable treatment outcomes for AML patients, confirming FOXM1 as a crucial target to overcome drug resistance.

Analysis of Tapered Fibre Optic Surface Plasmon Resonance Bio-Sensor Chip With Highly Perturbed Taper Profiles.

A numerical model based on the Transfer matrix method (TMM) is proposed for the first time to study the gold coated tapered fibre optic surface plasmon resonance (SPR) with eight different types of taper profiles namely linear, exponential-linear, Gaussian, quadratic, sinusoidal, error function type and highly perturbed taper profile so-called chirp type of profile. The performance in terms of sensitivity, full width at half maximum (FWHM), detection accuracy (D.A.

An unusual case of maxillary first molar with seven canals and the successful surgical recovery of a separated instrument.

This case report highlights the intricate anatomy of root canals and the challenges they pose for clinicians. A 26-year-old female patient presented to the department with a chief complaint of pain in her left upper back tooth region. After thorough clinical and radiographical examinations, the diagnosis of pulpal necrosis with symptomatic apical periodontitis in the maxillary left first molar was confirmed.

Color Doppler ultrasound in high-low risk pregnancies and its relationship to fetal outcomes: a cross-sectional study.

Objective: To calculate the multivessel color Doppler indices in high-risk and low-risk pregnancies and relate these to fetal outcomes.

Methods: The investigation involved 60 patients who were pregnant. The patients were separated into groups according to assessment of low and high risk.

Small-molecule inhibitors targeting FOXM1: Current challenges and future perspectives in cancer treatments.

Forkhead box (FOX) protein M1 (FOXM1) is a critical proliferation-associated transcription factor (TF) that is aberrantly overexpressed in the majority of human cancers and has also been implicated in poor prognosis. A comprehensive understanding of various aspects of this molecule has revealed its role in, cell proliferation, cell migration, invasion, angiogenesis and metastasis. The FOXM1 as a TF directly or indirectly regulates the expression of several target genes whose dysregulation is associated with almost all hallmarks of cancer.

High sensitivity detection of different pH ranges with rGO-nanocomposite coated eFBG sensor.

In the proposed work, a highly sensitive reduced graphene oxide (rGO) coated etched fiber Bragg grating (eFBG) pH sensor is developed and characterized. To create the sensing probe, a nanocomposite layer of rGO is coated over the unclad area of the eFBG. The analysis of rGO material has been done using different characterization tools such as UV-VIS-NIR spectroscopy, x-ray diffraction (XRD), and field emission scanning electron microscopy (FESEM).

Comparison of the sealing ability amongst orthograde apical plugs of mineral trioxide aggregate plus, mineral trioxide aggregate repair HP, and Biodentine after root resection: a bacterial leakage study.

This study aimed to analyse the effect of root-end resection on the sealing ability of orthograde apical plugs of three root-end filling materials (MTA Repair HP, Biodentine, MTA Plus) using the bacterial leakage method and compare it with the retrograde root-end filling technique. Eighty-four extracted mandibular premolar teeth with single root and single straight canals were selected and randomly divided into two main experimental groups (n = 36) depending on the apical plug placement technique and a control: Group I: orthograde technique, followed by root-end resection; Group II: retrograde root-end filling technique; one control Group III (n = 12): obturation with gutta-percha, followed by root-end resection. Experimental groups were further subdivided into three subgroups A, B, and C (n = 12) depending on the three different root-end filling materials used.

Fracture resistance of post and core in immediate and delayed post space in trauma simulated teeth.

Introduction: This research aims to assess and analyze the fracture resistance of GC Everstick post with separate composite core buildup and Edelweiss prefabricated resin composite post and core single unit into immediate and delayed post space prepared teeth.

Methods: A total of 120 extracted human mandibular premolars have been subjected to a standardized protocol of mechanical trauma to simulate tooth fracture. Teeth samples were randomly divided into four groups (n = 30) on the basis of time taken for the preparation of post space (approximately following root canal obturation and 24 h after root canal obturation) for the single unit Edelweiss post and core system and GC post with separate core buildup.

Live Biomass of : A Sustainable Method for Decoloration and Detoxification of Dyes in Water.

In this study, white-rot fungus, , collected from an unidentified fallen twig from Pathankot, Punjab, India, was used for biosorption of anionic Congo red and cationic Methylene blue dyes from an aqueous medium. The biosorption efficiency of the live biomass of was investigated to optimize biosorbent dosage, process time, concentrations of dyes, and pH of solutions. The results indicated that is more efficient than other reported bio-adsorbents for Congo red and Methylene blue dyes.

Comparison of Dentinal Tubular Penetration of Intracanal Heated and Preheated Sodium Hypochlorite Through Different Agitation Techniques.

Introduction: The efficacy of sodium hypochlorite (NaOCl) as an intracanal irrigant is widely debated in endodontic therapy. This study aimed to analyze and compare the penetration abilities of different modes of NaOCl application and assess the impact of various agitation strategies on promoting root canal cleanliness.

Materials And Methods: This study included 168 single-rooted mandibular premolars that were randomly divided into 8 groups.

Deep Neck Space Infection a Study of 150 Cases at Tertiary Care Hospital.

Deep neck space infection (DNSI) is the infection of the potential space in the Neck; in this study our aim is to identify various aetiological causes, common site, bacteriology, and complications arising from it. DNSI is traditionally managed by prompt surgical drainage of the abscess followed by culture specific antibiotics. It is a prospective cross sectional type of study done conducted on 150 patients suffering from DNSI, it was conducted from March 2019 to March 2020 (1 year duration) at Department of ENT and Head & Neck Surgery, A.

To Study the Role of Cartridge-Based Nucleic Acid Amplification Test (CBNAAT) in Early Diagnosis of Extra Pulmonary Tuberculosis.

Diagnosing EPTB is difficult as various clinical presentations are seen with paucibacillary nature of the disease. Maurya AK et al. (J Postgrad Med 58(3):185-189) AFB smear hasn't been much effective in diagnosing of EPTB.

Radicular dentinal microcracks during biomechanical root canal preparation using four minimally invasive endodontic files.

Aim: The aim of the study was to compare the dentinal microcrack formation on human mandibular molars using 4 different minimally invasive file systems at 3, 6 and 9 mm from apex using a stereomicroscope.

Method: 125 mesial roots of mandibular molars were randomly divided into 5 groups and instrumented (n=25). Group 1: Control Group (CG), Group 2: Self Adjusting File (SAF), Group 3: XP-Endoshaper (XP), Group 4: TRUShape (TS), Group 5: V Taper 2H (VT).

SPR Based Biosensing Chip for COVID-19 Diagnosis-A Review.

Surface Plasmon Resonance (SPR) techniques are highly accurate in detecting biomolecular like blood group measurement, food adulteration, milk adulteration and recently developing as a rapid detection for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. In order to validate the clinical diagnosis, Real-time reverse transcriptase-polymerase chain reaction (RT-PCR) of nasopharyngeal swabs has been utilized, which is time consuming and expensive. For fast and accurate detection of the SARS-CoV-2 virus, SPR based biosensing chips are described in this review article.

Numerical analysis of a grating embedded bidirectional integrated optical coupler pressure sensor.

A numerical analysis of a grating embedded bidirectional optical coupled waveguide structure is presented for the first time, to our knowledge. A finite difference method (FDM) based scheme is devised to extract the allowed eigen TE and TM modes of the structure. Sensing characteristics of the grating employed between two high refractive index couplers are then explored.

Role of Long Non-Coding RNAs in Human-Induced Pluripotent Stem Cells Derived Megakaryocytes: A p53, HOX Antisense Intergenic RNA Myeloid 1, and miR-125b Interaction Study.

Megakaryocytes (MKs) are rare polyploid cells found in the bone marrow and produce platelets. Platelets are small cell fragments that are essential during wound healing and vascular hemostasis. In vitro differentiation of MKs from human-induced pluripotent stem cell-derived CD34 hematopoietic stem cells (hiPSC-HSCs) could provide an alternative treatment option for thrombocytopenic patients as a platelet source.

A Numerical Study of Different Metal and Prism Choices in the Surface Plasmon Resonance Biosensor Chip for Human Blood Group Identification.

Optimized design of Surface plasmon resonance (SPR) based biosensor in terms of different metal choices and prisms are presented to the first time for the high precision detection of human blood group in near infrared wavelength range. The results are well compared with the earlier published gold coated silicon biosensor chip while discussing the pros and cons of various prism/metal choices. In this study buffer layer onto SPR active metal has been deployed to avoid the oxidation problem and contamination issue related with blood samples.

Multi-Detector CT Instillation Dacryocystography and Its Role in the Diagnosis of Lacrimal Drainage System Blocks.

To assess the use of Multi-detector computed tomography instillation dacryocystography (MDCT-DCG) and its role in the diagnosis of lacrimal drainage system (LDS) blocks. It is a prospective evaluation of Twenty-five cases presenting with symptoms with NLDO (nasolacrimal duct obstruction) assessed by MDCT-DCG. The study was conducted in LN medical college and JK hospital Bhopal (M.

Light emitting diode assessment of dentinal microcracks after root canal preparation with 4 different heat-treated file systems.

Background: The purpose of this research was to evaluate the dentinal microcracks formation after root canal preparation with Hyflex EDM ([electrical discharge machining], Coltene; Altstätten, Switzerland), Neolix Neoniti A1 EDM (Neolix; Beijing, China), Wave One Gold (Dentsply Sirona; York, PA, USA) and Edge File X1 (EdgeEndo; Albuquerque, NM, USA) under illumination and magnification.

Methods: One hundred fifty mandibular molars with 2 different mesial canals extracted for periodontal reasons were included in the study. The samples were decoronated at 15 mm from the apex using a carborundum disc under copious water cooling.

Radix entomolaris and radix paramolaris in mandibular molars: a case series and literature review.

The success of root canal treatment depends on complete debridement of pulp tissue from the root canals. Therefore, a thorough knowledge of unusual anatomical findings is of utmost importance. Although the majority of mandibular molars present with 2 roots (mesial and distal) and 3 or 4 root canals, the number of roots and root canals in individual molars may vary.