Publications by authors named "Raghuraman G Karunakaran"

Fabrication of charged, multiphasic, polymeric micro- and nanoparticles with precise control over their composition, size, and shape is critical for developing the next generation of drug carriers for combinatorial therapies and theranostics. The addition of charged polyelectrolyte multilayers on the surface of polymeric particles can significantly improve their stability, targeting efficacy, drug-release kinetics, and their ability to encapsulate different drugs within a single particle. Many of the traditional methods for multilayer functionalization of multiphasic polymeric particles are time and energy intensive which significantly limits their scalability, and therefore therapeutic potential.

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Precise control over the geometry and chemistry of multiphasic particles is of significant importance for a wide range of applications. In this work, we have developed one of the simplest methodologies for fabricating monodisperse, multiphasic micro- and nanoparticles possessing almost any composition, projected shape, modulus, and dimensions as small as 25 nm. The synthesis methodology involves the fabrication of a nonwettable surface patterned with monodisperse, wettable domains of different sizes and shapes.

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We study the nonwettability and transparency from the assembly of fluorosilane modified silica nanoparticles (F-SiO(2) NPs) via one-step spin-coating and dip-coating without any surface postpassivation steps. When spin-coating the hydrophobic NPs (100 nm in diameter) at a concentration ≥ 0.8 wt % in a fluorinated solvent, the surface exhibited superhydrophobicity with an advancing water contact angle greater than 150° and a water droplet (5 μL) roll-off angle less than 5°.

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We demonstrate, for the first time, the synthesis of model poly(benzyl methacrylate) [P(BnMA)] brushes of very high thickness (>300 nm) on silicon wafer. P(BnMA) brush is also synthesized from the surface of silica nanoparticles, from a covalently anchored initiator monolayer, using ambient temperature ATRP. The kinetic studies and block copolymerization from the surface anchored P(BnMA)-Br macroinitiator showed that the polymerization was controlled in nature.

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Article Synopsis
  • Researchers developed a method to create a transparent superhydrophobic surface using silica nanoparticles of two different sizes, achieving high water repellency with an advancing contact angle over 160°.
  • The process involved dip coating substrates with these nanoparticles and hydrophobilizing them with a special chemical, resulting in low roll-off angles for water droplets.
  • The superhydrophobic coating proved effective on various materials (like Si, glass, and fabrics) and maintained its properties even after prolonged UV exposure.
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