Safety and efficacy of platelet-rich plasma injection for treatment of erectile dysfunction: a prospective randomized controlled study.

Background: Affected sexual relationships affect both the quality of life of men and women. Platelet-derived therapies are becoming increasingly popular in various medical and surgical fields because of their ability to aid in tissue healing and vascular remodeling. This study aimed to assess the safety and effectiveness of platelet-rich plasma (PRP) injections in treating patients with erectile dysfunction (ED).

UPLC-HRMS/MS Guided Isolation and NMR Investigation of Major Flavonoids from Enarthrocarpus strangulatus Boissier (Brassicaceae) with In Vitro Enzymes Inhibitory Potential.

Various members of the family Brassicaceae are economically important and traditionally used to treat many disorders. Among the family members, Enarthrocarpus strangulatus Boissier is a common Egyptian species that was rarely studied. Consequently, the current study aims to characterize its phytochemical composition and assess its potential bioactivity comprehensively.

Investigating small sized metal blockage effects at 60 and 100 GHz using measurements and modeling approaches.

Millimeter wave (mmWave) technologies at 60 GHz and 100 GHz bands are currently gaining significant attention for its potential to meet the demanding needs of next-generation networks. These include ultra-high data rate, ultra-low latency, high spectral efficiency, and high end-to-end reliability. However, mmWave signals' blockage remains a critical issue that affects the reliability of mmWave at 60 GHz and at 100 GHz bands due to the significant attenuations induced by the blockers (BLs).

Machine learning-based classification of structured light modes under turbulence and eavesdropping effects.

This paper considers the classification of multiplexed structured light modes, aiming to bolster communication reliability and data transfer rates, particularly in challenging scenarios marked by turbulence and potential eavesdropping. An experimental free-space optic (FSO) system is established to transmit 16 modes [8-ary Laguerre Gaussian (LG) and 8-ary superposition LG (Mux-LG) mode patterns] over a 3-m FSO channel, accounting for interception threats and turbulence effects. To the best of authors' knowledge, this paper is the first to consider both factors concurrently.

Egypt Genome: Towards an African new genomic era.

Background: Studying the human genome is crucial to embrace precision medicine through tailoring treatment and prevention strategies to the unique genetic makeup and molecular information of individuals. After human genome project (1990-2003) generated the first full sequence of a human genome, there have been concerns towards Northern bias due to underrepresentation of other populations. Multiple countries have now established national genome projects aiming at the genomic knowledge that can be harnessed from their populations, which in turn can serve as a basis for their health care policies in the near future.

Shock wave lithotripsy in the era of COVID-19.

Objective: The objective of the study y was to evaluate factors which can improve shock wave lithotripsy (SWL) results to keep up with COVID-19 pandemic.

Methods: Between June 2020 and June 2021, patients with radio-opaque or faint radio-opaque upper urinary tract stones, stone attenuation value ≤1200 HU, and stones size <2.5 cm were treated by electrohydraulic SWL.

Serum and Tissue Lipocalin-2 Expression in Chronic Kidney Disease Pruritic Patients.

Background: Uremic pruritus is an irritating symptom for patients with end-stage kidney disease. Lipocalin-2 (LCN2) has relevant importance in several biological cellular processes and immunity. It is also a major player in the progression of many disorders, such as renal injury.

Multievent localization for loop-based Sagnac sensing system using machine learning.

In optical sensing applications such as pipeline monitoring and intrusion detection systems, accurate localization of the event is crucial for timely and effective response. This paper experimentally demonstrates multievent localization for long perimeter monitoring using a Sagnac interferometer loop sensor and machine learning techniques. The proposed method considers the multievent localization problem as a multilabel multiclassification problem by dividing the optical fiber into 250 segments.

Strain FBG-Based Sensor for Detecting Fence Intruders Using Machine Learning and Adaptive Thresholding.

This paper demonstrates an intruder detection system using a strain-based optical fiber Bragg grating (FBG), machine learning (ML), and adaptive thresholding to classify the intruder as no intruder, intruder, or wind at low levels of signal-to-noise ratio. We demonstrate the intruder detection system using a portion of a real fence manufactured and installed around one of the engineering college's gardens at King Saud University. The experimental results show that adaptive thresholding can help improve the performance of machine learning classifiers, such as linear discriminant analysis (LDA) or logistic regression algorithms in identifying an intruder's existence at low optical signal-to-noise ratio (OSNR) scenarios.

Anatomic considerations of inflatable penile prosthetics: lessons gleaned from surgical body donor workshops.

Surgical implantation of an inflatable penile prosthesis (IPP) remains the gold-standard treatment for severe erectile dysfunction. The ideal surgical technique requires a thorough understanding of the relevant anatomy. This includes anatomic considerations related to, but not limited to, dissection and exposure of penoscrotal fasciae and tissues, corporal configuration, and abdominal structures.

Value of prolonged scrotal drainage after penile prosthesis implantation: a multicenter prospective nonrandomized pilot study.

We aimed to understand the risks and benefits of post-inflatable penile prosthesis (IPP) implantation drainage and optimal duration. Our patients were divided into 3 groups: Group 1 (n = 114) had no drain placed, Group 2 had a drain placed for 24 h (n = 114) and Group 3 had a drain placed for 72 h (n = 117). Postoperative scrotal hematoma and prosthesis infection rates were compared between the groups.

Performance investigation of an ambiguity function-shaped waveform (AFSW) using a photonics-based radar system.

In this work, we investigate the performance of an ambiguity function-shaped waveform (AFSW) using a millimeter-wave photonics-based radar system at 100 GHz. An AFSW is a radar waveform whose ambiguity function can be shaped to increase the peak-to-sidelobe ratio (PSR) for better detectability of targets in a desired range/velocity region. To the best of the authors' knowledge, this paper is the first in the literature that investigates the performance of such a waveform in a photonics-based radar system.

MicroRNAs: Small Molecules with Significant Functions, Particularly in the Context of Viral Hepatitis B and C Infection.

A MicroRNA (miRNA) is defined as a small molecule of non-coding RNA (ncRNA). Its molecular size is about 20 nucleotides (nt), and it acts on gene expression's regulation at the post-transcription level through binding to the 3'untranslated regions (UTR), coding sequences, or 5'UTR of the target messenger RNAs (mRNAs), which leads to the suppression or degradation of the mRNA. In recent years, a huge evolution has identified the origin and function of miRNAs, focusing on their important effects in research and clinical applications.

Discriminative strain and temperature sensing using a ring-hyperbolic tangent fiber sensor.

Brillouin fiber sensors have demonstrated strong capability in discriminative and high-sensitivity multiparameter measurements. In this study, we proposed and numerically investigated novel ring core fiber-based stimulated Brillouin scattering for the simultaneous measurement of temperature and strain. The novel fiber, referred to as ring hyperbolic tangent (R-HTAN) fiber, is characterized by a shape parameter (α) that controls the optical refractive index and longitudinal acoustic velocity profiles.

Reconfigurable photonics-based millimeter wave signal aggregation for non-orthogonal multiple access.

A reconfigurable optical-to-electrical signal aggregation is proposed, for the first time, using optical signal processing and photo-mixing technology. Two optically modulated quadrature phase-shift keying (QPSK) signals are aggregated into a single 16-quadrature amplitude modulation (16-QAM) signal and, simultaneously, carried over a 28-GHz millimeter wave (MMW) carrier using an optimized heterodyne beating process through a single photodiode. To demonstrate the system reconfigurability, aggregation of two optical binary phase-shift keying signals is mapped into MMW QPSK or four-level pulse amplitude modulation signals by controlling the relative phases and amplitudes, respectively, of the input signals.

The Addition of Radiofrequency Tumor Ablation to Kyphoplasty May Reduce the Rate of Local Recurrence in Spinal Metastases Secondary to Breast Cancer.

Background: Approximately 10% of all cancer patients develop spinal metastases. When a symptomatic compression fracture occurs without associated deformity or neurologic deficit, it can be treated with kyphoplasty with or without radiofrequency ablation (RFA). Treatment with kyphoplasty is well established but does not address the underlying oncologic disease.

Combined Blood Indexes of Systemic Inflammation as a Mirror to Admission to Intensive Care Unit in COVID-19 Patients: A Multicentric Study.

Background: The Coronavirus 2019 is a pandemic that has spread worldwide, threatening human health. The main cause of death in patients with COVID-19 is a systemic pro-inflammatory mechanism that quickly progresses to acute respiratory distress syndrome. Hematological ratios as affordable indicators of inflammatory response were studied in COVID-19 patients.

ESSM Position Statement on Surgical Treatment of Peyronie's Disease.

Introduction: Patients with Peyronie's disease may experience significat distress. The choice of treatment depends on a variety of factors, including the stage of the disease, the presence of pain, severity and direction of the curvature, penile length and the quality of erectile function.

Aim: To review the evidence associated with surgical treatment of Peyronie`s Disease and provide clinical recommendations on behalf of the European Society for Sexual Medicine.

Naturally Available Flavonoid Aglycones as Potential Antiviral Drug Candidates against SARS-CoV-2.

Flavonoids are important secondary plant metabolites that have been studied for a long time for their therapeutic potential in inflammatory diseases because of their cytokine-modulatory effects. Five flavonoid aglycones were isolated and identified from the hydrolyzed aqueous methanol extracts of L., Blanco, and (L.

Validation of Coronary Artery Disease Reporting and Data System (CAD-RADS) and Application of Coronary Artery Calcium Data and Reporting System (CAC-DRS) as New Standardized Tools in the Management of Coronary Artery Disease Patients.

Background And Objectives: The coronary artery disease reporting and data system (CAD-RADS) is intended to standardize the reporting of CCTA and the subsequent management guidelines of CAD. The present study was conducted to investigate the validation of CAD-RADS and the application of coronary calcium grading in CAD management.

Patients And Methods: The current study is a single-center prospective study that involved 177 participants with chest pain who were submitted to coronary CT angiography (CCTA).

Bidirectional MMWoF-wireless convergence system based on a 1610 nm L-band quantum-dash laser.

We report bidirectional 25/28 GHz millimeter wave (MMW)-over-fiber (MMWoF) and MMWoF-wireless (MMWoF-WL) transmission systems employing a single self-injection locked InAs/InP quantum-dash dual-mode laser (QD-DML) as a MMW source. Besides, we demonstrate the entire system exploiting the challenging mid-L-band wavelength window (1610 nm) to substantiate this source's potential, which exhibits tunability from C- to L-bands, in next-generation optical networks covering these wavelengths' window operations. While exhibiting 28 GHz mode spacing between the two optical carriers of QD-DML, a downstream (DS) transmission of 4.

Fat mass and obesity-associated gene expression and disease severity in type 2 diabetes mellitus.

Unlabelled: Obesity and visceral adiposity are major risk factors for type 2 diabetes mellitus (T2DM). The fat mass and obesity-associated (FTO) gene is associated with increased risk of obesity and T2DM. The aim of this work was to study the association between FTO gene expression and serum FTO protein level with disease severity in T2DM patients.

A review of monoclonal antibodies in COVID-19: Role in immunotherapy, vaccine development and viral detection.

The harmful COVID-19 pandemic caused by the SARS-CoV-2 coronavirus imposes the scientific community to develop or find conventional curative drugs, protective vaccines, or passive immune strategies rapidly and efficiently. Passive immunity is based on recovering hyper-immune plasma from convalescent patients, or monoclonal antibodies with elevated titer of neutralizing antibodies with high antiviral activity, that have potential for both treatment and prevention. In this review, we focused on researching the potentiality of monoclonal antibodies for the prevention and treatment of COVID-19 infection.

Free space optic channel monitoring using machine learning.

Free space optic (FSO) is a type of optical communication where the signal is transmitted in free space instead of fiber cables. Because of this, the signal is subject to different types of impairments that affect its quality. Predicting these impairments help in automatic system diagnosis and building adaptive optical networks.