Alleviates Stress and Anxiety in a Zebrafish () Model.

The Ayurvedic medical system uses fruits of the plant to treat mental diseases, including schizophrenia. The goal of the current study was to assess the aqueous extract of fruit's ability to relieve stress and anxiety induced in zebrafish models using neuropharmacological evaluation, which included determining behavioral parameters in tests such as the T-maze, open tank test (OTT), and light-dark preference test (LDPT). After measuring the zebrafish survival rate for 96 h, the LC was found to be 5 µg.

The implementation of ZnS-SnS BM NPs for phenanthrene degradation: An adsorptive photocatalyst approach and its toxicity studies in adult zebrafish.

Phenanthrene is a persistent organic pollutant released by numerous industries. The purpose of the study is to construct a batch reactor for phenanthrene degradation using a bimetallic (BM) ZnS-SnS nanoparticle as a photocatalyst. ZnS-SnS BM NPs were used as a photocatalyst, employed from precursors Zinc acetate dihydrate and tin (II) chloride dihydrate, with crystalline cubic-shaped particle sizes.

T-2 toxin induces dermal inflammation and toxicity in mice: The healing potential of menthol.

According to the World Health Organization and the Food and Agricultural Organization of the United Nations, T-2 is one of the most harmful food-toxic chemicals, penetrates intact skin. The current study examined the protective benefits of menthol topical treatment on T-2 toxin-induced cutaneous toxicity in mice. Lesions were observed on the skin of the T-2 toxin-treated groups at 72 and 120 h.

Convalescent action of menthol against T-2 mycotoxin-induced toxicity: An in vitro study with HaCaT cells.

Only T-2 mycotoxin is emitted as an aerosol and is the most toxic fungal secondary metabolite among mycotoxins. In its clinical condition, the skin is severely irritated and painful due to lesions and alimentary toxic aleukia. Herein, we have assessed various bioactive molecules, viz.

Nanofabrication of cobalt-tellurium using Allium sativum extract and its protective efficacy against HO-induced oxidative damage in HaCaT cells.

Allium sativum (A. sativum)is well known for its therapeutic and culinary uses. Because of their high medicinal properties, the clove extract was selected to synthesize cobalt-tellurium nanoparticles.

Silk sericin conjugated magnesium oxide nanoparticles for its antioxidant, anti-aging, and anti-biofilm activities.

The Silk sericin protein was conjugated with magnesium oxide (MgO) nanoparticles to form SS-MgO-NPs . UV, XRD, FTIR, SEM, DLS, and EDX were used to confirm the formation of SS-MgO-NPs. The absorption band of SS-MgO-NPs using UV-visible spectra was observed at 310 nm, with an average size of the nanoparticles was 65-88 nm analyzed from DLS.

Attenuation of Hyperlipidemia by Medicinal Formulations of Synergized with Nanotechnological Approaches.

The ayurvedic herb () is a gift to mankind to acquire a healthy lifestyle. It has great therapeutic and nutritional importance. , also known as Indian gooseberry or Amla, is a member of the Euphorbiaceae family.

Immobilization of Polymers to Surfaces by Click Reaction for Photocatalysis with Recyclability.

A surface-bound photocatalyst offers advantages of reusability and recyclability with ease. While it can be immobilized by spin coating or drop-casting, a more reliable and durable method involves the formation of a self-assembled monolayer (SAM) on a suitable surface using designer molecules. In this paper, we report devising a practical, durable, and recyclable photocatalytic surface using immobilized polytriazoles of diketopyrrolopyrrole (DPP).

Advances in Nanofabrication Technology for Nutraceuticals: New Insights and Future Trends.

Bioactive components such as polyphenolics, flavonoids, bioactive peptides, pigments, and essential fatty acids were known to ward off some deadliest diseases. Nutraceuticals are those beneficial compounds that may be food or part of food that has come up with medical or health benefits. Nanoencapsulation and nanofabricated delivery systems are an imminent approach in the field of food sciences.

Green fabrication of silver nanoparticles using Chloroxylon swietenia leaves and their application towards dye degradation and food borne pathogens.

Green synthesized silver nanoparticles (AgNPs) are becoming an important candidate for bioremediation and biomedical applications. But in recent trends, more focus is given towards degradation of dyes and application against food pathogens. The synthesis of efficient AgNPs depends on the selection of potential biological material for synthesis.

An endophytic fungus, conjugated with C60 fullerene for its potential antimitotic, anti-inflammatory, anticancer and photodegradation activities.

In the present study, endophytic fungus, isolated from was used to analyze phytochemical studies by qualitative and GC-MS methods. The endophytic fungus yielded novel compound penisimplicissin identified through GC-MS studies. Further, was conjugated with C60 fullerene nanoparticles (Ps-FNPs) were verified using UV-vis spectra, XRD, FTIR, DLS, EDX and SEM.

Bio-Based Formulations for Sustainable Applications in Agri-Food-Pharma.

Currently, there is a strong enduring interest towards obtaining high-value, sustainable bio-based bioactive compounds from natural resources, as there is great demand for these compounds in various market sectors such as agriculture, food, pharma, cosmeceuticals, and others [...

In vitro therapeutic evaluation of nanoliposome loaded with Xyloglucans polysaccharides from Tamarindus flower extract.

Nanoparticles are interesting area of research developed for several diagnostic and therapeutic applications. Tamarind flower extract is rich in Xyloglucan, a starch like polysaccharide which promotes proliferation and various application areas like drug-delivery technology. In recent years researchers are evaluating nanoliposome using in vitro and in vivo studies to discover their biomedical applications.

Chaetomium globosum extract mediated gold nanoparticle synthesis and potent anti-inflammatory activity.

Gold nanoparticles (AuNPs) are gaining a lot of attention in recent decades from researchers due to their unique optoelectronic properties and their significance in the field of biomedicine. Keeping this in view, our research work was designed to investigate gold nanoparticles obtained by using a fungal endophytic strain Chaetomium globosum, isolated from Vitex negundo which showed significant activity on enzyme inhibition. In the present study, the fungal isolate C.

A systematic review on recent trends in transmission, diagnosis, prevention and imaging features of COVID-19.

As the new cases of COVID-19 are growing every daysince January 2020, the major way to control the spread wasthrough early diagnosis. Prevention and early diagnosis are the key strategies followed by most countries. This study presents the perspective of different modes of transmission of coronavirus,especially during clinical practices and among the pediatrics.

Biofabrication of gold nanoparticles mediated by the endophytic Cladosporium species: Photodegradation, in vitro anticancer activity and in vivo antitumor studies.

Green fabrication of nanoparticles (NPs) using biological sources is the fast-growing trend replacing chemical synthesis via toxic materials. Considering the importance and feasibility of green fabricated NPs, the present research focuses on the synthesis of gold nanoparticles (AuNPs) using the aqueous extract of the endophytic Cladosporium sp. (MycoAuNPs) isolated from Commiphora wightii.

Experimental and Theoretical Investigations of Different Diketopyrrolopyrrole-Based Polymers.

Diketopyrrolopyrrole (DPP)-based polymers are often considered as the most promising donor moiety in traditional bulk heterojunction solar cell devices. In this paper, we report the synthesis, characterization of various DPP-based copolymers with different molecular weights, and polydispersity where other aromatic repeating units (phenyl or thiophene based) are connected by alternate double bonds or triple bonds. Some of the copolymers were used for device fabrication and the crucial parameters such as fill factor (FF) and open circuit voltage ( ) were calculated.

Ultrasound-guided peripheral nerve interventions for common pain disorders.

There are a number of common pain disorders that can be managed effectively by injections around or ablation of peripheral nerves. Ultrasound is a universally available imaging tool, is safe, cost-effective, and is excellent in imaging many peripheral nerves and guiding needles to the site of the nerves. This article aims to present an overview of indications and techniques of such procedures that can be effectively performed by a radiologist.

Cyanoacrylate adhesive embolization and sclerotherapy for primary varicose veins.

Various treatment methods are available for the treatment of varicose veins, and there has been a recent surge in the usage of cyanoacrylate glue for treating varicose veins. Purpose To investigate the technical possibility, efficiency and safety of cyanoacrylate adhesive embolization and sclerotherapy using commonly available n-butyl cyanoacrylate glue for the treatment of primary varicose veins due to great saphenous vein reflux with or without incompetent perforators. Materials and Methods One hundred forty-five limbs of 124 patients with varicose veins due to great saphenous vein reflux were subjected to cyanoacrylate adhesive embolization and sclerotherapy - adhesive embolization of great saphenous vein in the thigh and perforators using cyanoacrylate followed by sclerotherapy of any residual varicose veins in the leg.

Prevalence of facial asymmetry in Tirupati population: A posteroanterior cephalometric and photographic study.

Aims And Objective: The human face is the most prominent aspect in human social interactions, and therefore, it seems reasonable opting for orthodontic treatment is to overcome psychosocial difficulties relating to facial and dental appearance and enhance the quality of life in doing so.

Materials And Methods: Posteroanterior cephalograms and frontal photographs of 100 participants (50 males and 50 females) were analyzed to evaluate skeletal asymmetry by the analysis suggested by Grummons. Soft tissue facial asymmetry was analyzed by composite photographic analysis.

Spinal Epidural Varices, a great Mimic of Intervertebral Disc Prolapse - A Case Series.

Introduction: Epidural venous plexus enlargement, presenting with low back pain and radiculopathy, is an uncommon cause of nerve roots impingement. This condition commonly mimics a herniated nucleus pulposus radiologically. The radiological diagnosis is often missed and the diagnosis is made during the surgery.

Role of astrocytic S100beta in behavioral hypersensitivity in rodent models of neuropathic pain.

S100beta is a calcium-binding peptide produced mainly by astrocytes that exerts paracrine and autocrine effects on neurons and glia. We have previously shown that S100beta is markedly elevated at the mRNA level in the spinal cord following peripheral inflammation, intraplantar administration of complete Freund's adjuvant in the rat. The purpose of the present study was to further investigate the role of astrocytic S100beta in mediating behavioral hypersensitivity in rodent models of persistent pain.

Complete Freunds adjuvant-induced peripheral inflammation evokes glial activation and proinflammatory cytokine expression in the CNS.

Peripheral inflammation induces central sensitization characterized by the development of allodynia and hyperalgesia to mechanical and thermal stimuli. Recent evidence suggests that activation of glial cells and a subsequent increase in proinflammatory cytokines contribute to the development of behavioral hypersensitivity after nerve injury or peripheral inflammation. In the present study, we examined mRNA and protein expression of glial markers and proinflammatory cytokines at the lumbar spinal cord, brainstem and forebrain following intraplantar administration of complete Freunds adjuvant (CFA) in rats.

Quantitative real-time RT-PCR assessment of spinal microglial and astrocytic activation markers in a rat model of neuropathic pain.

Activated spinal glial cells have been strongly implicated in the development and maintenance of persistent pain states following a variety of stimuli including traumatic nerve injury. The present study was conducted to characterize the time course of surface markers indicative of microglial and astrocytic activation at the transcriptional level following an L5 nerve transection that results in behavioral hypersensitivity. Male Sprague-Dawley rats were divided into a normal group, a sham surgery group with an L5 spinal nerve exposure and an L5 spinal nerve transected group.