Spatiotemporal distribution of air pollutants during a heat wave-induced forest fire event in Uttarakhand.

Prevailing dry conditions and rainfall deficit during the spring season in North India led to heat wave conditions which resulted in widespread and intense forest fire events in the Himalayan state of Uttarakhand during April 16-30, 2022. A total of 7589 active fires were detected by VIIRS during the second half of April 2022 compared to 1558 during the first half. The TROPOMI observed total column values of CO and NO increased by 4.

The role of continental evapotranspiration on water vapour isotopic variability in the troposphere.

Rainforests play an important role in hydrological and carbon cycles, both at regional and global scales. They pump large quantities of moisture from the soil to the atmosphere and are major rainfall hotspots of the world. Satellite-observed stable water isotope ratios have played an essential role in determining sources of moisture in the atmosphere.

Climate plays a dominant role over land management in governing soil carbon dynamics in North Western Himalayas.

The soil carbon (C) dynamics is strongly influenced by climate and land-use patterns in the Himalayas. Therefore, soils under five prominent land use [e.g.

Integrated agroforestry systems improve soil carbon storage, water productivity, and economic returns in the marginal land of the semi-arid region.

Environmental crises, land degradation, and frequent crop failure threaten the livelihoods of millions of the populace in the semi-arid agroecosystems. Therefore, different combinations of annual crops with perennial fruit trees were assessed to restore the soil carbon, and enhance farm productivity and profitability in a semi-arid climate. The study hypothesized that the integration of perennial fruit trees with seasonal crops may enhance farm productivity, economic returns, and environmental sustainability.

Assessment of soil enzymatic resilience in chlorpyrifos contaminated soils by biochar aided Pelargonium graveolens L. plantation.

Chlorpyrifos (CP), a broad-spectrum organophosphorus insecticide, is known for deleterious effects on soil enzymatic activities. Hence, the present study aims to examine the resilience effect of biochar (BC) aided Pelargonium graveolens L. plantation on enzymatic activities of chlorpyrifos contaminated soil.

Exploring agricultural waste biomass for energy, food and feed production and pollution mitigation: A review.

Globally agricultural production system generates a huge amount of solid waste. Improper agri-waste management causes environmental pollution which resulted in economic losses and human health-related problems. Hence, there is an urgent need to design and develop eco-friendly, cost-effective, and socially acceptable agri-waste management technologies.

Restoring soil carbon in marginal land of Indian Himalayas: Impact of crop intensification and conservation tillage.

Soil carbon (C) loss is the prime sign of land degradation, and C pools have a great impact on soil quality and climate change mitigation. Hence, a field experiment was conducted for three consecutive years to assess the impact of crop intensification and conservation tillage practices on changes in the C pool at different soil depths of marginal land of the Indian Himalayas. The experiment consisted of two intensified cropping systems viz.

Uncontrolled mitochondrial calcium uptake underlies the pathogenesis of neurodegeneration in MICU1-deficient mice and patients.

Dysregulation of mitochondrial Ca homeostasis has been linked to neurodegenerative diseases. Mitochondrial Ca uptake is mediated via the calcium uniporter complex that is primarily regulated by MICU1, a Ca-sensing gatekeeper. Recently, human patients with MICU1 loss-of-function mutations were diagnosed with neuromuscular and cognitive impairments.

Aminoacid Profiling of Children with Severe Acute Malnutrition Pre and Post Nutritional Rehabilitation.

Malnutrition is a significant comorbidity in nearly one-third of the 8 million deaths in children under five years of age worldwide. Children with severe acute malnutrition have severely disturbed physiology and metabolism. Considering the vital importance of amino acids and the likely changes with the therapeutic diet, we aimed at evaluating these changes in children with SAM at baseline and after rehabilitation with a therapeutic diet at 14 days.

Nanofertilizers for agricultural and environmental sustainability.

Indiscriminate use of chemical fertilizers in the agricultural production systems to keep pace with the food and nutritional demand of the galloping population had an adverse impact on ecosystem services and environmental quality. Hence, an alternative mechanism is to be developed to enhance farm production and environmental sustainability. A nanohybrid construct like nanofertilizers (NFs) is an excellent alternative to overcome the negative impact of traditional chemical fertilizers.

Ameliorative effects of biochar on persistency, dissipation, and toxicity of atrazine in three contrasting soils.

The presence of atrazine a persistent herbicide in soil poses a serious threat to the ecosystem. The biochar amendment in soil altered the fate of this herbicide by modifying the soil properties. The present study examines the dissipation and toxicity of atrazine in three contrasting soils (silty clay, sandy loam, and sandy clay) without and with biochar amendment (4%).

Endophytic bacterium CIMAP-A7 mediated amelioration of atrazine induced phyto-toxicity in Andrographis paniculata.

The presence of atrazine, a triazine herbicide, and its residues in agriculture soil poses a serious threat to human health and environment through accumulation in edible plant parts. Hence, the present study focused on atrazine induced stress amelioration of Andrographis paniculata, an important medicinal plant, by a plant growth promoting and atrazine degrading endophytic bacterium CIMAP-A7 inoculation. Atrazine has a non-significant effect at a lower dose while at a higher dose (lower: 25 and higher: 50 mg kg) 22 and 36% decrease in secondary metabolite content and plant dry weight of A.

Biochar amendment reduced the risk associated with metal uptake and improved metabolite content in medicinal herbs.

Contaminations of heavy metals such as lead (Pb) and cadmium (Cd) in medicinal plants (MPs) not only restrict their safe consumption due to health hazards but also lower their productivity. Biochar amendments in the soil are supposed to immobilize the toxic metals, improve the soil quality and agricultural productivity. However, the impact of biochar on growth attributes, metal accumulation, pharmacologically active compounds of MPs, and health risk is less explored.

Impact of 28 year old agroforestry systems on soil carbon dynamics in Eastern Himalayas.

Globally, various estimates are available on the above-ground (plant parts) carbon (C) sequestering potential of agroforestry systems (AFSs). However, information on soil organic carbon (SOC) sequestration potential is limited for AFSs. Furthermore, the impacts of AFSs established for the restoration of C in degraded soils (prone to soil erosion, C and nutrients loss, etc.

Impact of land configuration and organic nutrient management on productivity, quality and soil properties under baby corn in Eastern Himalayas.

Appropriate land configuration and assured nutrient supply are prerequisites for quality organic baby corn (Zea mays L.) production in high rainfall areas of the delicate Eastern Himalayan Region of India. A long term (5-year) study was conducted during 2012-2016 on a sandy loam soil in the mid attitude of Sikkim, Eastern Himalayan Region of India to evaluate the productivity, produce quality, the profitability of baby corn, and soil properties under different land configurations comprising flatbed, ridge and furrow, and broad bed and furrow, and organic nutrient management practices comprising un-amended control, farmyard manure 12 t ha, vermicompost 4 t ha and farmyard manure 6 t ha + vermicompost 2 t ha.

Designing energy-efficient, economically sustainable and environmentally safe cropping system for the rainfed maize-fallow land of the Eastern Himalayas.

Achieving a circular economic model in agriculture and meeting the food requirement of the growing population is a global challenge. The task is much more daunting in the Eastern Himalaya where low productive maize-fallow is a predominant production system. To enhance system productivity and energy use efficiency while maintaining environmental sustainability and economic profitability, therefore, energy-efficient, low carbon footprint (CF; CO-e) and profitable short duration crops must be made an integral part of the maize fallow system.

Onset of summer monsoon in Northeast India is preceded by enhanced transpiration.

Variations in isotopic composition of water vapor in the atmosphere is an important indicator of the processes within the hydrological cycle. Isotopic signature of water vapor and precipitation can be helpful in partitioning evaporation and transpiration fluxes. It is well known that transpiration from forested regions supplies a significant amount of vapor to the atmosphere in monsoon and post-monsoon seasons.

Biochar aided aromatic grass [Cymbopogon martini (Roxb.) Wats.] vegetation: A sustainable method for stabilization of highly acidic mine waste.

Dumping of acidic mine waste poses severe threats to the ecosystem due to high acidity, nutrient deficiency and mobility of toxic metals. The present study has been undertaken on phytoremediation by amending the acidic soil/mine waste with biochar (BC) and plantation of palmarosa (Cymbopogon martini (Roxb.) Wats.

Dysregulation of Mitochondrial Ca Uptake and Sarcolemma Repair Underlie Muscle Weakness and Wasting in Patients and Mice Lacking MICU1.

Muscle function is regulated by Ca, which mediates excitation-contraction coupling, energy metabolism, adaptation to exercise, and sarcolemmal repair. Several of these actions rely on Ca delivery to the mitochondrial matrix via the mitochondrial Ca uniporter, the pore of which is formed by mitochondrial calcium uniporter (MCU). MCU's gatekeeping and cooperative activation are controlled by MICU1.

Indian Academy of Pediatrics Guidelines on the Fast and Junk Foods, Sugar Sweetened Beverages, Fruit Juices, and Energy Drinks.

Justification: In view of easy availability and increasing trend of consumption of fast foods and sugar sweetened beverages (fruit juices and drinks, carbonated drinks, energy drinks) in Indian children, and their association with increasing obesity and related non-communicable diseases, there is a need to develop guidelines related to consumption of foods and drinks that have the potential to increase this problem in children and adolescents.

Objectives: To review the evidence and formulate consensus statements related to terminology, magnitude of problem and possible ill effects of junk foods, fast foods, sugar-sweetened beverages and carbonated drinks; and to formulate recommendations for limiting consumption of these foods and beverages in Indian children and adolescents.

Process: A National Consultative group constituted by the Nutrition Chapter of the Indian Academy of Pediatrics (IAP), consisting of various stakeholders in private and public sector, reviewed the literature and existing guidelines and policy regulations.

Low Levels of Prohibitin in Substantia Nigra Makes Dopaminergic Neurons Vulnerable in Parkinson's Disease.

Since substantia nigra (SN) and ventral tegmental area (VTA) dopaminergic neurons are, respectively, susceptible or largely unaffected in Parkinson's disease (PD), we searched for protein(s) that regulates this differential sensitivity. Differentially, expressed proteins in SN and VTA were investigated employing two-directional gel electrophoresis- matrix-assisted laser desorption ionization time of flight (MALDI-TOF-TOF) analyses. Prohibitin, which is involved in mitochondrial integrity, was validated using immunoblot, qRT-PCR, and immunohistochemistry in normal mice as well as 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-model, PD postmortem human brains, and PD cybrids.

Structural insights into the regulation of NADPH binding to reductase domains of nonribosomal peptide synthetases: A concerted loop movement model.

The termination module of nonribosomal peptide synthetases (NRPS) and polyketide synthases (PKS) offloads the final product as an acid (occasionally also accompanied by cyclization) upon hydrolysis by employing thioesterase domains (TE-domains). Reductase domains (R-domains) of short-chain dehydrogenase/reductase (SDR) family offer an alternative offloading mechanism by reducing 4'-phosphopantetheine (4'-PPant) arm-tethered peptidyl chain, a thioester, to an aldehyde or an alcohol. Recent studies have highlighted their functional importance, for instance in the glycopeptidolipid (GPL) biosynthesis of Mycobacterium smegmatis, where the resulting alcoholic group is the site for subsequent modifications such as glycosylations.

Analysing Local Sparseness in the Macaque Brain Network.

Understanding the network structure of long distance pathways in the brain is a necessary step towards developing an insight into the brain's function, organization and evolution. Dense global subnetworks of these pathways have often been studied, primarily due to their functional implications. Instead we study sparse local subnetworks of the pathways to establish the role of a brain area in enabling shortest path communication between its non-adjacent topological neighbours.

Mitochondrial Deficits Accompany Cognitive Decline Following Single Bilateral Intracerebroventricular Streptozotocin.

Background: Bilateral intracerebroventricular (ICV) administration of streptozotocin (STZ) causes Alzheimer's disease (AD)-type neurodegeneration in rats. The model is increasingly used for investigating pathology and therapeutic strategies for AD.

Objective: The present study investigated cognitive abilities in rats infused with STZ-ICV in relation to hippocampal and cortical mitochondrial functions during a period of 60 days.