Publications by authors named "Raghava Varma"
India, a country with the second largest population in the world, does not have a national newborn screening programme as part of its health policy. With funding support from the Grand Challenges Canada, a pilot newborn screening programme was implemented for the Udupi district of South India to study the need and viability of a national programme in India. Six disorders were selected for the study based on the availability of funding and recommendation from pediatricians in the district.
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- Ritonavir and Lopinavir were studied to see how they work together in a co-amorphous state to achieve supersaturation and how this affects their solubility and flux.
- The research involved preparing co-amorphous materials using the quench cool method and analyzing them through techniques like XRPD, DSC, and FTIR, as well as conducting solubility and diffusion tests.
- Findings indicated that while co-amorphous materials can create a supersaturated state, there is a reduction in solubility based on the composition; however, a specific ratio (2:1) showed improved flux compared to each drug alone, likely due to better drug release mechanics.