Publications by authors named "Raghava Rao Gandra"
Prevalence of co-existent COVID-19-associated pulmonary aspergillosis (CAPA) and its impact on early mortality in patients with COVID-19-associated pulmonary mucormycosis (CAPM).
Mycoses
May 2024
Article Synopsis
- A study analyzed mixed mould infections in patients with COVID-19-associated pulmonary mucormycosis (CAPM) to determine the prevalence of co-existing COVID-19-associated pulmonary aspergillosis (CAPA) and its impact on early mortality.
- Among 105 patients with CAPM, 20% had mixed mould infections, and those with CAPA experienced significantly higher early mortality rates (42.9%) compared to those without (17.9%).
- The findings suggest that co-existing CAPA worsens the prognosis for CAPM patients, highlighting the need for further research on mixed mould infections globally.
Risk factors, mortality, and predictors of survival in COVID-19-associated pulmonary mucormycosis: a multicentre retrospective study from India.
Clin Microbiol Infect
March 2024
Article Synopsis
- The study aims to compare COVID-19-associated pulmonary mucormycosis (CAPM) with COVID-19-associated rhino-orbital mucormycosis (CAROM), identify factors linked to CAPM, and determine 12-week mortality predictors in CAPM patients.
- Researchers conducted a retrospective analysis involving 1724 COVID-19 patients, assessing demographics and illness details, and found that CAPM had higher rates of male sex, hypoxemia, and certain health conditions compared to CAROM.
- Results showed that CAPM had higher 12-week mortality (52.3%) than CAROM (30.5%), with factors like hypoxemia and Aspergillus co-infection increasing mortality risk, while
A randomized controlled trial comparing non-invasive ventilation delivered using neurally adjusted ventilator assist (NAVA) or adaptive support ventilation (ASV) in patients with acute exacerbation of chronic obstructive pulmonary disease.
J Crit Care
June 2023
Purpose: No study has compared neurally adjusted ventilator assist (NAVA) with adaptive support ventilation (ASV) during non-invasive ventilation (NIV) in subjects with acute exacerbation of chronic obstructive pulmonary disease (AECOPD).
Materials And Methods: In this randomized controlled trial, we compared NAVA-NIV with ASV-NIV for delivering NIV in consecutive subjects with AECOPD. The primary outcome was NIV failure rate (invasive mechanical ventilation).
Background: There are sparse data on the role of flexible bronchoscopy (FB) in diagnosing invasive mould infections (IMIs).
Objective: To investigate the safety and usefulness of FB in IMI. We evaluate the factors associated with a successful diagnosis of IMI using FB.
Background: The use of neurally-adjusted ventilatory assist (NAVA) during noninvasive ventilation (NIV) results in better patient-ventilator interaction. Whether this improves clinical outcomes lacks dedicated study.
Methods: In this randomized controlled trial, we compared NAVA with PSV for delivering NIV in consecutive subjects with de novo acute respiratory failure.