Publications by authors named "Raghava Jagadeesh Salaka"
NMDA-type glutamate receptors (NMDARs) are widely recognized as master regulators of synaptic plasticity, most notably for driving long-term changes in synapse size and strength that support learning. NMDARs are unique among neurotransmitter receptors in that they require binding of both neurotransmitter (glutamate) and co-agonist (e.g.
View Article and Find Full Text PDFUnlabelled: NMDA-type glutamate receptors (NMDARs) are widely recognized as master regulators of synaptic plasticity, most notably for driving long-term changes in synapse size and strength that support learning. NMDARs are unique among neurotransmitter receptors in that they require binding of both neurotransmitter (glutamate) and co-agonist (e.g.
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- Temporal lobe epilepsy (TLE) is the most prevalent focal epilepsy and is primarily managed with anti-seizure drugs (ASDs), such as levetiracetam (LEV), which target the SV2A protein.
- Despite extensive research on LEV's effects in acute epilepsy models, its impact on chronic epilepsy regarding neuronal excitability, synaptic plasticity, neurogenesis, and histological changes remains understudied.
- In a study of epileptic rats, LEV treatment improved synaptic transmission and structural changes in hippocampal regions but did not reverse all aspects of abnormal neurogenesis, sprouting, or anxiety-like behavior caused by chronic epilepsy.
Sleep dysfunctions in epilepsy increase the burden of seizures and cognitive impairments. Seizures and certain anti-seizure drugs (ASDs) can affect sleep quality, leading to excessive daytime sleepiness and poor cognitive performance. Therefore, it is imperative to develop non-pharmacological strategies to curb epilepsy and related sleep dysfunction.
View Article and Find Full Text PDFTemporal lobe epilepsy (TLE) is the most common form of focal epilepsies. Pharmacoresistance and comorbidities pose significant challenges to its treatment necessitating the development of non-pharmacological approaches. In an earlier study, exposure to enriched environment (EE) reduced seizure frequency and duration and ameliorated chronic epilepsy-induced depression in rats.
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