Subchondral Cellular Density Decreases with Increasing Grade of Cartilage Degeneration in Knee Osteoarthritis - An Ex vivo Histopathological Analysis.

Introduction: Subchondral milieu has been the region of interest in recent clinical trials demonstrating it as an effective treatment focus in knee osteoarthritis (OA). However, a systematic analysis of the subchondral cell population density is lacking in knee OA. Hence, this study aims to analyze the cell population density of the subchondral zone for every stage of cartilage degeneration to analyze the rationale behind this evolving treatment method for knee OA.