Publications by authors named "Ragav Chona"
Theranostics
October 2024
Article Synopsis
- Brain pericytes can change into multiple cell types after injury, but different subsets might have varied abilities to do so based on their characteristics.
- Using an ischemic stroke model and advanced techniques like single-cell RNA sequencing, researchers identified two main pericyte subpopulations (NG2 and Tbx18) that respond differently to brain injury: NG2 pericytes are more likely to turn into neurons, while Tbx18 pericytes can become endothelial cells, fibroblasts, and microglia.
- Additionally, by manipulating AMP-dependent kinase (AMPK) activity, the study found ways to enhance the conversion of pericytes into functional neurons, implying that targeted treatments could improve neuron formation from pericytes after
