Optimization and assessment of a hybrid geothermal heat pump and wind turbine system in Izmir, Turkey: A 4E analysis approach.

This study explores the optimization and performance of a hybrid energy system combining a geothermal heat pump (GHP) with a wind turbine in Izmir, Turkey. Utilizing a 4E (Energy, Exergy, Economic, and Exergoenvironmental) analysis approach, the system aims to enhance winter heating efficiency. Geothermal heat pumps leverage the Earth's consistent temperatures for heating and cooling, offering a sustainable alternative to traditional energy sources.

Exploring a novel thiazole derivatives hybrid with fluorinated-indenoquinoxaline as dual inhibitors targeting VEGFR2/AKT and apoptosis inducers against hepatocellular carcinoma with docking simulation.

Hepatocellular carcinoma (HCC) ranks as the third most prevalent reason for cancer-related death on a global scale. Tyrosine kinase inhibitors (TKIs) continue to be the primary treatment option for advanced hepatocellular carcinoma. A series of fluoro-11H-indeno[1,2-b]quinoxaline derivatives as an HCC drug targeting the VEGFR2/AKT axis was designed and synthesized.

Sustainable synthesis and environmental application of chitosan-Ocimum basilicum leaves-ZnO composite membrane for permanganate ion removal in wastewater treatment.

This study introduces a novel and environmentally friendly method for developing a cross-linked chitosan-Ocimum basilicum leaves-ZnO (ChOBLZnO) composite membrane, specifically designed for the adsorption of permanganate ions (MnO-) from wastewater. Various characterization techniques, including Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and Brunauer-Emmett-Teller (BET) surface area analysis, were employed to confirm the membrane's synthesis quality, structural integrity, and surface properties crucial for adsorption. The BET analysis revealed a surface area of 228.

Evaluation of seminal plasma levels of vaspin and visfatin in infertile males with elevated sperm DNA fragmentation index: a comparative study.

Background: Sperm DNA fragmentation (SDF) can significantly impact male fertility, especially in cases where there is a substantial level of DNA damage. We aimed in the current study to assess seminal plasma (SP) levels of vaspin and visfatin in infertile men with an elevated SDF index (SDFI ≥ 30%) compared to infertile males with a normal SDFI (SDFI < 30%).

Results: Groups with good and medium DNA integrity exhibited significantly higher total motile sperm count and sperm motility in comparison to the group with poor DNA integrity.

Optimizing Prognostic Precision in Hepatocellular Carcinoma: Integrating PWR with ALBI and PALPI Scores.

Background: Enhancing prognostication in Hepatocellular Carcinoma (HCC) remains an unmet need, especially in patients with preserved liver function. This study aimed to integrate the Platelet-to-White Blood Cell Ratio (PWR) with albumin-bilirubin (ALBI) and platelets-albumin-bilirubin (PALBI) scores for improved assessment of mortality and treatment responses in hepatocellular carcinoma (HCC) patients.

Methods: In this prospective study, 262 patients with hepatocellular carcinoma (HCC) were included, with basic data collected and followed up for one year or until death.

MobileNet-V2 /IFHO model for Accurate Detection of early-stage diabetic retinopathy.

Diabetic retinopathy is a serious eye disease that may lead to loss of vision if it is not treated. Early detection is crucial in preventing further vision impairment and enabling timely interventions. Despite notable advancements in AI-based methods for detecting diabetic retinopathy, researchers are still striving to enhance the efficiency of these techniques.

Evaluation of serum irisin level and severity of erectile dysfunction in diabetic males: a cross sectional prospective study.

Background: Irisin is an exercise-induced myokine that alleviates endothelial dysfunction and reduces insulin resistance in type 2 diabetes mellitus (T2DM). The current study aimed to assess the serum level of irisin in T2DM men with erectile dysfunction (ED) compared to T2DM patients with normal erectile function and healthy controls, as well as investigate the association between serum irisin level and the severity of ED in T2DM patients.

Patients And Methods: A cross-sectional study was conducted on 90 males, divided into three groups: 32 T2DM patients with ED, 24 T2DM patients without ED, and 34 healthy controls.

Inflammatory protein associations with brain MRI measures: Framingham Offspring Cohort.

Introduction: Brain magnetic resonance imaging (MRI) and inflammatory biomarkers are crucial for investigating preclinical neurocognitive disorders. Current investigations focus on a few inflammatory markers. The study aims to investigate the associations between inflammatory biomarkers and MRI measures and to examine sex differences among the associations in the Framingham Heart Study.

Assessing the Predictive Accuracy of the aMAP Risk Score for Hepatocellular Carcinoma (HCC): Diagnostic Test Accuracy and Meta-analysis.

Purpose: We aimed to perform a meta-analysis with the intention of evaluating the reliability and test accuracy of the aMAP risk score in the identification of HCC.

Methods: A systematic search was performed in PubMed, Scopus, Cochrane, Embase, and Web of Science databases from inception to September 2023, to identify studies measuring the aMAP score in patients for the purpose of predicting the occurrence or recurrence of HCC. The meta-analysis was performed using the meta package in R version 4.

Serum Testosterone-Estradiol Ratio in Toxoplasma-Seropositive Infertile Men: A Prospective, Single-Center Study.

Background: The purpose of the current study was to compare the testosteroneestradiol (T:E2) ratio in Toxoplasma gondii seropositive infertile men with seropositive and seronegative normozoospermic controls.

Methods: Totally, 200 men with normal virilization, 100 with idiopathic infertility and 100 normozoospermic men, were included. Participants underwent medical history assessment, physical examination, semen analysis, testing for T.

Insight into divergent chemical modifications of chitosan biopolymer: Review.

Chitosan is used in many applications due to its biodegradability, biocompatibility, nontoxicity, nonadhesiveness, and film-forming capabilities. Chitosan has antibacterial and antifungal activities, which are two of its other desirable attributes. However, chitosan can only dissolve in acidic liquids (1-3 % acetic acid), limiting its practical application.

Unveiling anti-diabetic potential of new thiazole-sulfonamide derivatives: Design, synthesis, in vitro bio-evaluation targeting DPP-4, α-glucosidase, and α-amylase with in-silico ADMET and docking simulation.

Diabetes mellitus type 2 (T2DM) can be managed by targeting dipeptidyl peptidase-4 (DPP-4), an enzyme that breaks down and deactivates peptides such as GIP and GLP-1. In this context, a new series of 2-(2-substituted hydrazineyl)thiazole derivatives 4, 5, 6, 8, 10, and 11 conjugated with the 2-hydroxy-5-(pyrrolidin-1-ylsulfonyl)benzylidene fragment were designed and synthesized. The virtual screening of the designed derivatives inside DPP-4 demonstrated good to moderate activity, with binding affinity ranging from -6.

Numerical analysis of the impact of winding angles on the mechanical performance of filament wound type 4 composite pressure vessels for compressed hydrogen gas storage.

Transportation relies heavily on petroleum products, forcing the adoption of alternative energy sources like hydrogen. Hydrogen is considered the cleanest fuel for the twenty-first century due to its water-based combustion and no CO emissions. However, challenges persist in production, utilization, and storage; employing composite material-based high-pressure storage vessels is increasing in the hydrogen storage sector.

Impacts of rifaximin and midodrine on morbidity, mortality, and quality of life in patients with decompensated liver cirrhosis.

Background: Vasodilatation and bacterial dislocation are the main contributors to the catastrophic events in patients with decompensated liver cirrhosis (DLC).

Aim: The aim of this study was to evaluate the impacts of adding midodrine and rifaximin on morbidity, mortality, and quality of life in patients with DLC.

Methods: This interventional clinical study included 100 consecutively enrolled DLC patients randomized 1 : 1 into two groups.

Sodium alginate-encapsulated nano-iron oxide coupled with copper-based MOFs (Cu-BTC@Alg/FeO): Versatile composites for eco-friendly and effective elimination of Rhodamine B dye in wastewater purification.

This study explores the effectiveness of Alginate-coated nano‑iron oxide combined with copper-based MOFs (Cu-BTC@Alg/FeO) composites for the sustainable and efficient removal of Rhodamine B (RhB) dye from wastewater through adsorption and photocatalysis. Utilizing various characterization techniques such as FTIR, XRD, SEM, and TEM, we confirmed the optimal synthesis of this composite. The composites exhibit a significant surface area of approximately 160 m g, as revealed by BET analysis, resulting in an impressive adsorption capacity of 200 mg g and a removal efficiency of 97 %.

Exploring the sustainable elimination of dye using cellulose nanofibrils- vinyl resin based nanofiltration membranes.

This study focuses on the development of a novel self-cleaning nanofiltration membrane for the efficient removal of the cationic dye methylene blue (MB) from industrial wastewater. The membrane is composed of vinyl resin (VR), cellulose nanofibrils (CNF), and titanium alpha aluminate (TAAL) nanoparticles.The TAAL loading ranged from 1 to 5 wt%, the pH varied from 5 to 10, and the initial MB concentration ranged from 10 to 50 ppm.

Fluorinated indeno-quinoxaline bearing thiazole moieties as hypoglycaemic agents targeting -amylase, and -glucosidase: synthesis, molecular docking, and ADMET studies.

Inhibition of α-glucosidase and -amylase are key tactics for managing blood glucose levels. Currently, stronger, and more accessible inhibitors are needed to treat diabetes. Indeno[1,2-] quinoxalines-carrying thiazole hybrids were created and described using NMR.

New prospective insecticidal agents based on thiazolo[4,5-b]quinoxaline derivatives against cotton leafworm Spodoptera litura (Fabricius): Design, synthesis, toxicological, morphology, histological, and biomedical studies.

In this study, a new series of thiazolo[4,5-b]quinoxaline derivatives 3-8 were synthesized by treating 2,3-dichloroquinoxaline with thiosemicarbazone and thiourea derivatives under reflux conditions. The chemical structure of the newly designed derivatives was conducted using spectroscopic techniques. The insecticidal bioassay of the designed derivatives was evaluated against the 2nd and 4th larvae of S.

Discovery of new anti-diabetic potential agents based on paracetamol incorporating sulfa-drugs: Design, synthesis, α-amylase, and α-glucosidase inhibitors with molecular docking simulation.

Uncontrolled diabetes can lead to hyperglycemia, which causes neuropathy, heart attacks, retinopathy, and nervous system damage over time, therefore, controlling hyperglycemia using potential drug target inhibitors is a promising strategy. This work focused on synthesizing new derivatives via the diazo group, using a hybridization strategy involving two approved drugs, paracetamol and several sulfonamides. The newly designed diazo-paracetamols 5-12 were fully characterized and then screened for in vitro α-amylase and α-glucosidase activities and exhibited inhibitory percentages (IP) = 92.

No drains versus drains after perforated peptic ulcer repair: A randomized controlled trail.

Purpose: The study aimed to evaluate safety of omitting the intraabdominal drains after perforated peptic ulcer repairs.

Materials And Methods: We conducted a prospective, randomized, controlled trial from January 2022 to January 2024 at the Emergency surgery department. Patients with perforated peptic ulcers were evaluated for eligibility.

Immune cell phenotypes and mortality in the Framingham Heart Study.

Background: Global life expectancy is rising, with the 60 + age group projected to hit 2 billion by 2050. Aging impacts the immune system. A notable marker of immune system aging is the presence of Aging-Related Immune Cell Phenotypes (ARIPs).