Publications by authors named "Rafka Challita"

Article Synopsis
  • - Bladder cancer is a common diagnosis among men, with cystectomy being the main treatment, but newer approaches like radiotherapy and chemotherapy can improve patient outcomes and quality of life.
  • - Approximately 20% of patients may eventually need salvage cystectomy due to resistance to radiation therapy, emphasizing the importance of developing tests that can predict how well tumors respond to radiation.
  • - The review focuses on research efforts to understand bladder cancer's radiosensitivity and identify potential biomarkers to create effective predictive assays for treatment personalization.
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Children with cancer previously treated with radiotherapy face the likelihood of side effects that can be debilitating or fatal. This study aimed to assess the long-term effect of medulloblastoma radiotherapy on the DNA double-strand break (DSB) repair capability of primary fibroblasts derived from lung biopsies of previously irradiated young sheep. This study included biopsies from three control and five irradiated sheep.

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Background: Early-stage breast cancer is usually treated with breast-conserving surgery followed by adjuvant radiation therapy. Acute skin toxicity is a common radiation-induced side effect experienced by many patients. Recently, a combination of bisphosphonates (zoledronic acid) and statins (pravastatin), or ZOPRA, was shown to radio-protect normal tissues by enhancing DNA double-strand breaks (DSB) repair mechanism.

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