Climate change impact on water treatment plants: analysis of chlorophyll-a levels and process performance.

Climate change significantly impacts the risk of eutrophication and, consequently, chlorophyll-a (Chl-a) concentrations. Understanding the impact of water flows is a crucial first step in developing insights into future patterns of change and associated risks. In this study, the Statistical DownScaling Model (SDSM)-a widely used daily downscaling method-is implemented to produce downscaled local climate variables, which serve as input for simulating future hydro-climate conditions using a hydrological model.

Selective Ni-Catalyzed Cross-Electrophile Coupling of Heteroaryl Chlorides and Aryl Bromides at 1:1 Substrate Ratio.

Nickel-catalyzed cross-electrophile coupling (XEC) reactions of (hetero)aryl electrophiles represent appealing alternatives to palladium-catalyzed methods for biaryl synthesis, but they often generate significant quantities of homocoupling and/or proto-dehalogenation side products. In this study, an informer library of heteroaryl chloride and aryl bromide coupling partners is used to identify Ni-catalyzed XEC conditions that access high selectivity for the cross-product when using equimolar quantities of the two substrates. Two different catalyst systems are identified that show complementary scope and broad functional-group tolerance, and time-course data suggest that the two methods follow different mechanisms.

Association of MicroRNA-103 expression with type 2 diabetes mellitus.

Background: Type 2 diabetes mellitus (T2DM), the most prevalent metabolic disorder worldwide, has genetic, epigenetic, and environmental contributors. Among them, circulating microRNAs (miRNAs/miRs) have attracted considerable attention. This study aimed to investigate the regulatory role of miR-103 in T2DM development.

Non-coding RNA biosensors for early detection of brain cancer.

Brain cancer remains a formidable challenge with limited treatment options. Non-coding RNAs (ncRNAs) have emerged as promising biomarkers due to their dysregulation in tumorigenesis. This review explores the potential of biosensors for early detection of brain cancer by targeting ncRNAs.

Progesterone decreases viability and up regulates membrane progesterone receptors expression on the human Chronic Myeloid Leukemia cell line.

Progesterone (P4) has an important effect (activatory or inhibitory) on cell proliferation. Although there is evidence of the impact of progesterone on sex-linked cancers, it can affect other cancer cells expressing P4 receptors (PRs). We evaluated the expression of membrane P4 receptors (mPRs) and the viability in progesterone-treated K562 cells to inspect the possible effects route of progesterone on this (CML) cancer cell line.

Comprehensive review of artifacts in cardiac MRI and their mitigation.

Cardiac magnetic resonance imaging (CMR) is an important clinical tool that obtains high-quality images for assessment of cardiac morphology, function, and tissue characteristics. However, the technique may be prone to artifacts that may limit the diagnostic interpretation of images. This article reviews common artifacts which may appear in CMR exams by describing their appearance, the challenges they mitigate true pathology, and offering possible solutions to reduce their impact.

The effect of COVID-19 anxiety on nurses' productivity determinants through perceived workload and individual job performance: A Bayesian mediation analysis.

This study aims to predict how COVID-19 anxiety affects productivity determinants by examining the role of perceived workload and individual job performance as mediators using Bayesian mediation analysis. To achieve the study's objectives, all nurses working at Imam Reza Hospital were recruited to participate. To gather data, all eligible and voluntary nurses were asked to complete questionnaires that included the Corona Disease Anxiety Scale (CDAS), Individual Job Performance Questionnaire (IJPQ), NASA Task Load Index (NASA-TLX), and Workforce Productivity Questionnaire.

Non-injection drug use among incarcerated people in Iran: Findings from three consecutive national bio-behavioral surveys.

Background: Prisons often serve as high-risk environments for drug use, and incarcerated people are at a high risk for substance use-related mental and physical harms. This study aimed to determine the prevalence of non-injection drug use inside the prison and its related factors among incarcerated people in Iran.

Methods: We utilized data from three national bio-behavioral surveillance surveys conducted among incarcerated people in Iran in 2009, 2013, and 2017.

Strategic Framework for Strengthening Health Laboratory Services in the COVID-19 Pandemic in Iran.

Background & Objective: Providing equitable access to good quality, timely, and affordable laboratory testing has always been a top priority for the Ministry of Health and Medical Education (MoH-ME) and the Reference Health Laboratory (RHL). Considering the significant role of medical laboratories in disease surveillance, RHL developed a strategic plan to manage laboratory services during the COVID-19 pandemic based on the "Strategic Framework for strengthening health laboratory services, 2016-2020" proposed by the World Health Organization (WHO). This article describes the steps taken to establish the strategic framework in Iran.

Investigating Blood Lead Levels and Its Health Effects on Employees of a Petroleum Industry and the Surrounding Residents: A Case Study of Kirkuk City, Iraq.

Objective: This study has been aimed to investigate factors associated with elevated blood lead levels (BLLs) across different percentiles in individuals employed in the petroleum industry and residents of Kirkuk City . In addition, to provide evidence-based approaches to mitigate exposure risks and safeguard vulnerable populations.

Methods: The study involved 357 participants and utilized quantile regression to examine BLL in petroleum industry workers and Kirkuk residents.

Clinical utility of a rapid two-dimensional balanced steady-state free precession sequence with deep learning reconstruction.

Background: Cardiovascular magnetic resonance (CMR) cine imaging is still limited by long acquisition times. This study evaluated the clinical utility of an accelerated two-dimensional (2D) cine sequence with deep learning reconstruction (Sonic DL) to decrease acquisition time without compromising quantitative volumetry or image quality.

Methods: A sub-study using 16 participants was performed using Sonic DL at two different acceleration factors (8× and 12×).

Exploring Blood Lead Level Determinants in Refinery Workers: A Cross-Sectional Study.

Background: Occupational lead exposure poses a significant risk to workers in industrial settings, especially in petroleum refineries. The study aimed to examine the prevalence and determinants of high blood lead concentrations among refinery workers in Kirkuk, Iraq. It has also been aimed to provide evidence-based approaches to identify associated risk factors.

MicroRNAs utilization as effective factors on hematopoietic stem cell transplantation, its outcomes and prognosis; a comprehensive systematic review.

Introduction: The therapeutic method for many malignant and non-malignant diseases is hematopoietic stem cell transplantation (HSCT), but it is not always fully successful in all patients. Indeed, HSCT can be influenced by a variety of factors. Here we reviewed the effect of microRNAs (miRs) on HSCT-related outcomes, like survival, infections, relapse, engraftment, and so on, systematically.

Isolation of lytic bacteriophages and their relationships with the adherence genes of Staphylococcus saprophyticus.

Objective: This study aimed to introduce a lytic bacteriophage against Staphylococcus saprophyticus from wastewater in Gorgan, northern Iran.

Results: The vB_SsapS-46 phage was isolated from urban wastewater and formed round and clear plaques on bacterial culture. It was visualized by electron microscopy and had a large head (approximately 106 nm) and a long tail (approximately 150 nm), indicating that it belongs to the Siphoviridae family.

Dynamics of antimicrobial resistance and susceptibility profile in full-scale hospital wastewater treatment plants.

Drug resistance has become a matter of great concern, with many bacteria now resist multiple antibiotics. This study depicts the occurrence of antibiotic-resistant bacteria (ARB) and resistance patterns in five full-scale hospital wastewater treatment plants (WWTPs). Samples of raw influent wastewater, as well as pre- and post-disinfected effluents, were monitored for targeted ARB and resistance genes in September 2022 and February 2023.

Analyzing sustainability in bread production: a life cycle assessment approach to energy, exergy and environmental footprint.

Bread production is a pivotal component of global nutrition. However, its extensive production imposes significant strain on resources and energy, resulting in substantial environmental consequences. This study focuses on a multidimensional assessment of the environmental sustainability of the bread life cycle as a case study in Iran.

Single-nucleus proteomics identifies regulators of protein transport.

The physiological response of a cell to stimulation depends on its proteome configuration. Therefore, the abundance variation of regulatory proteins across unstimulated single cells can be associatively linked with their response to stimulation. Here we developed an approach that leverages this association across individual cells and nuclei to systematically identify potential regulators of biological processes, followed by targeted validation.

Therapeutic Effects of Mesenchymal Stem Cell-Derived Extracellular Vesicles in sepsis: a Systematic Review and Meta-Analysis of Preclinical Studies.

Background: Sepsis is a life-threatening disorder with no definitive cure. Preclinical studies suggest that extracellular vesicles derived from mesenchymal stromal cells (EV-MSCs) can mitigate inflammatory conditions, potentially leading to increased survival and reduced organ dysfunction during sepsis. Our aim to conduct this systematic review and meta-analysis is assessing the EV-MSCs therapeutic efficacy in sepsis.