The effect of body positioning on gastroesophageal reflux in premature infants: evaluation by combined impedance and pH monitoring.

Objective: To evaluate the pattern of acid and nonacid gastroesophageal reflux (GER) in different body positions in preterm infants with reflux symptoms by a combined multichannel intraluminal impedance (MII)-pH monitoring, which identifies both acid and nonacid GER.

Study Design: Premature infants with frequent regurgitation and postprandial desaturation (n = 22) underwent a 24-hour recording of MII-pH. In a within-subjects design, reflux indexes were analyzed with the infants in 4 different positions: supine (S), prone (P), on the right side (RS), and on the left side (LS).

Starch thickening of human milk is ineffective in reducing the gastroesophageal reflux in preterm infants: a crossover study using intraluminal impedance.

We evaluated the efficacy of the thickening of human milk by precooked starch in reducing gastroesophageal reflux in preterm infants. Five preterm infants with frequent regurgitations (median gestational age, 28 weeks; range, 27 to 32 weeks; median birth weight, 990 g; range, 570 to 1900 g) were fed alternately during 24 hours with four meals of fortified maternal milk (milk A) and four meals of fortified maternal milk thickened by 1.5 g of precooked starch per 100 mL of milk (milk B).

Intrauterine growth retardation is a risk factor for cisapride-induced QT prolongation in preterm infants.

Background: Cisapride is a possible cause of potentially life threatening QT prolongation.

Aims: We investigated these cardiac side effects in premature infants, mainly in relation to fetal growth.

Patients: Forty six preterms (mean birth weight 1.