Mnemic disturbances occurred in 8 of 14 subjects during a pharmcopsychological investigation of possible interactions between alcohol and dipotassium chlorazepate (Tranxilium). The blood alcohol concentrations were between 0.87% and 1.
View Article and Find Full Text PDFInt J Clin Pharmacol Biopharm
May 1979
The effect of a single dosage of 20 mg dipotassium clorazepate (DPC) on reaction times, with and without administration of ethanol (1 g/kg body weight), was studied in 14 male subjects. When administered in the evening, the sort-term effect of DPC consisted of slightly increased optic reaction times and decreased endurance and concentration. With simultaneous administration of ethanol, all types of performance studied were significantly impaired; impairment was more pronounced than with the ethanol tests.
View Article and Find Full Text PDFInt J Clin Pharmacol Biopharm
December 1977
The influence of alcohol in combination with the preparation Mobiletten on the psycho-physical efficiency was studied in 15 probands by way of various test methods. Under alcohol and, at the same time, Mobiletten influence, the probands showed significantly less efficiency loss in regard to single test parameters than under alcohol without intake of the substance to be tested. The changes were noted in a comparison of the test results obtained at respective points of time as well as those obtained when the blood ethanol concentrations were practically identical.
View Article and Find Full Text PDFInt J Clin Pharmacol Biopharm
July 1977
The interaction of the drug Mobiletten with the pharmacokinetics of ethanol was studied in 15 probands. In these experiments, the maximal ethanol concentrations in blood were found to be significantly decreased and delayed. The ethanol elimination remained unchanged.
View Article and Find Full Text PDFThe authors describe the extremely rare finding of a keratinized squamous cell carcinoma of the bladder in a 13 year old girl without however a history of the typical symptoms of the illness such as hematuria. The findings are reviewed in the light of the current literature. Enuresis leading to a chronic infection of the urinary tract is discussed as the possible etiologic factor.
View Article and Find Full Text PDFBeitr Gerichtl Med
December 1976