Influence of Dimerization of Lipopeptide Laur-Orn-Orn-Cys-NH and an -terminal Peptide of Human Lactoferricin on Biological Activity.

Lactoferrin (LF) is a naturally occurring antimicrobial peptide that is cleaved by pepsin to lactoferricin (LFcin). LFcin has an enhanced antimicrobial activity as compared to that of LF. Recently several hetero- and homodimeric antimicrobial peptides stabilized by a single disulfide bond linking linear polypeptide chains have been discovered.