Neoadjuvant chemotherapy with or without oxaliplatin after short-course radiotherapy in high-risk rectal cancer: A subgroup analysis from a prospective study.

Aim: To evaluate the role of oxaliplatin in neoadjuvant chemotherapy delivered after short-course irradiation.

Background: Using oxaliplatin in the above setting is uncertain.

Patients And Methods: A subgroup of 136 patients managed by short-course radiotherapy and 3 cycles of consolidation chemotherapy within the framework of a randomised study was included in this post-hoc analysis.

Preoperative radiotherapy and local excision of rectal cancer: Long-term results of a randomised study.

Background And Purpose: It is uncertain whether local control is acceptable after preoperative radiotherapy and local excision (LE). An optimal preoperative dose/fractionation schedule has not yet been established.

Material And Methods: In a phase III study, patients with cT1-2N0M0 or borderline cT2/T3N0M0 < 4 cm rectal adenocarcinomas were randomised to receive either 5 × 5 Gy plus 1 × 4 Gy boost or chemoradiation: 50.

Collision tumour of the stomach--adenocarcinoma and neuroendocrine carcinoma: case report and review of the literature.

We report a rare case of gastric collision tumour composed of poorly differentiated adenocarcinoma and neuroendocrine carcinoma in a 56-year-old Caucasian male. The tumour was located in the gastric body and, to our knowledge, it is the tenth case described in the literature and the first in Poland. The adenocarcinoma component constituted 20% of the lesion and was in a more advanced stage than the neuroendocrine component.

Preoperative radiotherapy and local excision of rectal cancer with immediate radical re-operation for poor responders.

Background And Purpose: To report an early analysis of prospective study exploring preoperative radiotherapy and local excision in rectal cancer.

Materials And Methods: Mucosa at tumour edges was tattooed. Patients with cT1-3N0 tumour <3-4 cm were treated with either 5x5Gy+4Gy boost (N=31) or chemoradiation (50.

Distal intramural spread of rectal cancer after preoperative radiotherapy: the results of a multicenter randomized clinical study.

Purpose: To evaluate the extent of distal intramural spread (DIS) after preoperative radiotherapy for rectal cancer.

Methods And Materials: A total of 316 patients with T(3-4) primary resectable rectal cancer were randomized to receive either preoperative 5x5 Gy radiation with immediate surgery or chemoradiation (50.4 Gy, 1.

Total cystectomies in the surgical treatment of rectal cancer with prior chemoradiation: analysis of postoperative morbidity and survival.

Background And Aims: Curative surgery for rectal cancer seldom requires urinary tract resections. The study investigated morbidity and survival following resection of rectum with total cystectomy following chemoradiation for primary rectal cancer.

Patients And Methods: 19 consecutive patients with primary nonresectable rectal cancer undergoing preoperative chemoradiation and operated on by a multidisciplinary team of surgeons.