Publications by authors named "Rafal Marian Kaminski"
A pharmacokinetic/pharmacodynamic (PK/PD) model was developed to describe the time course of writhings after intraperitoneal injection of acetic acid in mice. The model was applied to investigate the antinociceptive effect of trazodone and gabapentin alone and in combination. Writhings time course was described by a transit compartment model with the delay due to the transit of the acetic acid being represented by a chain of intermediate compartments.
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- De novo mutations in the GRIN2B gene, which encodes the GluN2B subunit of the NMDA receptor, are linked to severe epilepsy in children, such as infantile spasms.
- The study tested the effects of radiprodil, a specific inhibitor of GluN2B, on altered glutamate currents in oocytes injected with various mutated GRIN2B mRNAs, finding that while radiprodil maintained its blocking ability, other NMDA inhibitors were less effective.
- The research suggests that the heightened function of certain GRIN2B variants contributes to increased neuronal activity in epilepsy, indicating that radiprodil could be a promising treatment for these pediatric conditions.