Hyperoxia and brain: the link between necessity and injury from a molecular perspective.

Oxygen (O) supplementation is commonly used to treat hypoxia in patients with respiratory failure. However, indiscriminate use can lead to hyperoxia, a condition detrimental to living tissues, particularly the brain. The brain is sensitive to reactive oxygen species (ROS) and inflammation caused by high concentrations of O, which can result in brain damage and mitochondrial dysfunction, common features of neurodegenerative disorders.

Short-term hyperoxia induced mitochondrial respiratory chain complexes dysfunction and oxidative stress in lung of rats.

Background: Oxygen therapy is an alternative for many patients with hypoxemia. However, this practice can be dangerous as oxygen is closely associated with the development of oxidative stress.

Methods: Male Wistar rats were exposed to hyperoxia with a 40% fraction of inspired oxygen (FIO) and hyperoxia (FIO = 60%) for 120 min.

Socioeconomic and demographic profile of occupational morbidity and mortality in Brazil from 2009 to 2016.

Introduction: Occupational accidents occur as a result of work, and can lead to bodily harm or functional impairments that lead to death, or to the reduction or loss of working capacity. Occupational accidents are associated with two possible outcomes: morbidity or mortality. Morbidity refers to the subset of a population that develops an illness over a given period of time, while mortality refers to the number of individuals who die over a specified time period.