Publications by authors named "Rafaella F A Costa"
Background: Crohn's disease (CD) is characterized by chronic inflammation of the human intestine. Several studies have demonstrated that the intestinal mucosa of CD patients in Western countries is abnormally colonized by adherent-invasive Escherichia coli (AIEC) strains. However, no studies to date have focused on the involvement of such E.
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- The study investigates the duodenal ulcer promoting gene A (dupA) in Helicobacter pylori, focusing on identifying mutations that could affect its function.
- Thirty-four strains showed mutations leading to truncated versions of the dupA gene, impacting their classification as dupA-positive.
- The presence of the complete dupA gene was significantly linked to duodenal ulcers compared to other conditions, suggesting its potential use as a disease marker.