Publications by authors named "Rafaela de Siqueira Ferraz-Carvalho"

This study assessed the SARS-CoV-2 surrogate bacteriophage φ6 cross-contamination between high-density polyethylene or polyvinyl chloride gloves and fruits (tomato and cucumber) using different inoculum levels (6.0 and 4.0 log PFU/sample).

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The present study aimed to evaluate the in vitro antibacterial and antibiofilm activity of bacterial cellulose hydrogel produced by sp. (HYDROGEL) containing vancomycin (VAN) against bacterial strains that cause wound infections, such as multidrug-resistant (MDR) and . Initially, HYDROGEL was obtained from sugar cane molasses, and scanning electron microscopy (SEM) was performed to determine morphological characteristics.

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Article Synopsis
  • * Ozone treatment showed significant reduction of MS2 in black mulberry (up to 3.6 log PFU/g) and pitanga (up to 4.1 log PFU/g), while PDT-curcumin achieved reductions of 3.2 log PFU/g in black mulberry and 4.8 log PFU/g in pitanga.
  • * The study found that both methods led to disintegration of MS2 particles, suggesting their potential for creating effective strategies to control Norovirus on fruits and surfaces.
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  • This study investigated how effectively citral nanoemulsion (CN) can kill Listeria monocytogenes on fresh-cut melon and papaya over a week-long storage period at different temperatures (4, 8, 12, and 16 °C).
  • The CN-0.3 formulation significantly reduced L. monocytogenes counts below detection levels after 48 hours at 4 °C and 72 hours at 8 °C and 12 °C, while also exhibiting a notable impact on the fruit's native microbiota.
  • Additionally, fruits treated with CN-0.3 maintained better sensory qualities such as brightness, flavor, and firmness, alongside minimal changes in sugar and organic acid levels, demonstrating
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Different carrier systems have been investigated for myocardial delivery of biopharmaceuticals for heart disease. Here, we aimed to evaluate the heart retention and tissue response of liposomes intended for cardiac drug delivery. Liposomes were produced by the lipid thin film hydration method followed by sonication.

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The present study describes the use of fucoidan, a negative sulfated polysaccharide, as a coating material for the development of liposomes targeted to macrophages infected with . First, fucoidan was chemically modified to obtain a hydrophobized-fucoidan derivative (cholesteryl-fucoidan) using a two-step microwave-assisted (μW) method. The total reaction time was decreased from 14 hours to 1 hour while maintaining the overall yield.

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Pain is a phenomenon present in the majority of the population, affecting, among others, the elderly, overweight people, and especially recently operated patients, analgesia being necessary. In the specific case of relief of postoperative pain, different kinds of anesthetics are being used, among them bupivacaine, a widely used drug which promotes long-lasting analgesic effects. However, cardiotoxicity and neurotoxicity are related to its repetitive use.

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The impact of the addition of L. acidophilus La-05 (free cells, microencapsulated with alginate [30 g/L] or microencapsulated with alginate coated with chitosan [5 g/L]) on the quality parameters of spreadable goat Ricotta cheese during storage (7 °C/7 days) was evaluated. The addition of probiotic culture resulted in products with lower hardness, gumminess, and springiness, as well as higher cohesiveness and adhesiveness.

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The effect of microencapsulation of L. acidophilus La-05 (8 log CFU/mL) by external ionic gelation technique in alginate (30 g/L; AM) and alginate coated with a low molecular weight chitosan solution (5 g/L; AC5M) on the survival of the freeze-dried probiotic culture during storage (7 °C; 0, 7, 15, 30, 60, 90 and 120 days), and exposure to temperature (72, 85 and 90 °C), pH (2, 4, and 6), and NaCl (10, 15 and 20 g/L) were studied. Furthermore, vegan milks (soybean and rice milks) added with microencapsulated probiotic cultures were evaluated for the physicochemical characteristics and survival of the probiotic culture during refrigerated storage (7 °C; 7 days) and in vitro digestion.

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Purpose: To determine the release profile of moxifloxacin encapsulated in liposomes in the aqueous humor as a controlled release system for intracameral application.

Methods: Liposomes containing moxifloxacin were obtained using the lipid film hydration method and were characterized by particle size and encapsulation efficiency. Female rabbits were used for the in vivo profile release study.

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Cashew nut allergy is the second most commonly reported tree nut allergy. Traditional allergen immunotherapy presents several clinical drawbacks that can be reduced by using nanoparticles-basedallergen-delivery systems, modulating the immune response towards a protective one. In this context, the goal of this work was to assess the potential of poly(anhydride) nanoparticles (NP) for cashew nut oral immunization.

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