Publications by authors named "Rafaela Soares Senra da Costa"
To investigate the association of genetic polymorphisms GlnArg and LeuMet of Paraoxonase 1 () gene, and ArgHis of Sulfotransferase 1A1 () gene with occurrence of breast cancer among young women living in Rio de Janeiro city. This is a hospital-based case-control study including 265 women aged 18-35 years, diagnosed with breast cancer at National Cancer Institute; and 277 controls in the same age group selected among women patients and companions of three general hospitals from Rio de Janeiro public health network. Polymorphisms genotyping was performed using the PCR-RFLP technique.
View Article and Find Full Text PDFBlood levels of metallic chemical element exposure patterns and associated factors in a population living in an Industrial District in Brazil.
J Trace Elem Med Biol
September 2024
Article Synopsis
- The study aimed to estimate the levels of various metallic elements in the blood of people living near a Steel company in Santa Cruz, Brazil, and to see if living close to the company was linked to higher metal concentrations.
- A total of 463 residents aged 18 and older were analyzed, measuring metals like Cadmium (Cd) and Lead (Pb) through blood samples, and distances from their homes to the Steel company were recorded using GPS.
- The results showed that for every kilometer further from the Steel company, there was a 19% decrease in blood levels of harmful metals like Cd, Al, and Pb, suggesting lower exposure with increased distance, while no significant links were found for other metals after adjustments.
Gene-Environment Interaction between Arg72Pro SNP and Selected Environmental Exposures among Brazilian Women Diagnosed with Benign Breast Disease.
Asian Pac J Cancer Prev
December 2020
Background: Benign breast disease (BBD) is a factor strongly associated with breast cancer worldwide. Arg72Pro SNP association with breast cancer is controversial due to the suggestion that environmental factors are required to modulate such risk. There are no studies evaluating these environmental interactions of the aforementioned SNP within BBD.
View Article and Find Full Text PDFP53 Expression in benign Breast Disease Development: A Systematic Review.
Asian Pac J Cancer Prev
September 2020
Background: Benign breast disease (BBD) is one of main breast cancer risk factors. Dysfunctions on p53 protein, which has a genome protective role, have been related to breast cancer developments. However, its role on BBD development is still unclear.
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