Publications by authors named "Rafaela Oliveira Matos"
Pesticide exposure and oxidative stress generation are linked to poor prognosis outcomes in breast cancer women carrying the allelic variant rs7438135 in the UGT2B7 gene.
Beatriz Geovana Leite Vacario Isabely Mayara da Silva Murilo Galvani Machado Julia Fernandes Gois Orrutéa Aline Graciele Henriques Campos Rafaela Oliveira Matos
J Biochem Mol Toxicol
November 2024
Article Synopsis
- Pesticide exposure is linked to an increased risk of diseases like breast cancer (BC), and the UGT2B7 gene variant rs7438135 (G > A) plays a role in detoxifying pesticides and potentially reducing oxidative stress.
- A study examined 228 women with BC to see how their UGT2B7 variant affected oxidative stress caused by pesticide exposure, measuring specific markers in their plasma.
- Results indicated that the rs7438135 variant did not provide protection against oxidative stress from pesticides, with significant lipid peroxidation and other stress markers observed in various aggressive tumor conditions.