Effect of juice and its phenolic metabolites on insulin resistance markers in overweight individuals and on microglial cell activity.

(PS) is a species of wild Brazilian passion fruit, rich in bioactive compounds. Scientific evidence suggests that food rich in polyphenols can modulate inflammation, thereby playing an important role in preventing chronic non-communicable diseases, such as type 2 diabetes (DT2) and cardiovascular diseases (CVD). This study aimed to investigate the effect of PS consumption on metabolic and inflammatory biomarkers in overweight male volunteers and to identify the underlying mechanism of action using an study using phenolic metabolites isolated from the plasma of volunteers at physiologically relevant concentrations.