Publications by authors named "Rafaela M Oliveira"
Blau syndrome is an autosomal dominant chronic inflammatory disease, which may begin with skin manifestations in the first months of life, alerting physicians to the diagnosis. This case reports a patient diagnosed jointly by pediatric dermatology and rheumatology consultants at two years of age.
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- Clomiphene citrate (CC) and letrozole are ovulatory stimulants associated with high ovulation rates but low pregnancy rates, prompting a study to evaluate their effects on apoptosis in human cumulus cells.
- The study involved primary cell cultures from IVF patients and utilized various assays to assess cell viability and gene expression; results showed that while these treatments did not significantly affect cell viability, letrozole reduced the percentage of cells in the S phase and CC increased certain gene expressions related to apoptosis.
- Overall, the findings suggest that CC and letrozole may influence cumulus cells at a cellular level and affect gene expression related to cell death, indicating potential direct effects beyond their traditional roles as ovulatory stimulants.