Publications by authors named "Rafaela G De Jesus"
Molecular characterization of metastatic penile squamous cell carcinoma in developing countries and its impact on clinical outcomes: LACOG 2018 translational study.
Oncologist
September 2024
Article Synopsis
- Penile squamous cell carcinoma (PSCC) is a rare cancer, more prevalent in developing countries, and understanding its molecular changes can help in finding better treatments.
- A study of 23 Brazilian mPSCC patients revealed that most had clinically significant genomic alterations, with high PD-L1 expression in 63.6% of cases and specific mutations linked to worse survival rates.
- The findings indicate similar molecular characteristics between developing and developed countries, highlighting potential for targeted therapies, despite the lack of predictive biomarkers for immunotherapy like TMB high or MSI.
The Impact of Fibroblast Growth Factor Receptor Alterations in Clinical Outcomes of Patients With Advanced Urothelial Carcinoma: Real-World Data From a Latin American Population.
Clin Genitourin Cancer
October 2024
Introduction: Fibroblast growth factor receptor (FGFR) mutations and fusions are relevant biomarkers in metastatic urothelial carcinoma (mUC). However, the prevalence of genomic alterations and their impact on clinical outcomes in a Latin American population remains unknown. This study aimed to explore the prevalence of FGFR mutations and/or fusions in patients with mUC in Latin America (LATAM) and its association with clinicopathological characteristics, Bellmunt's prognostic model, and survival outcomes.
View Article and Find Full Text PDFObjective: To analyze marital outcomes, divorce or separation, and its association with demographic, socioeconomic, and clinicopathological factors among breast cancer (BC) survivors after 2-years of diagnosis.
Methods: We performed a retrospective analysis of marital status at baseline and at years 1 and 2 of follow-up of women aged ≥ 18 years diagnosed with invasive BC participating in the AMAZONA III (GBECAM0115) study. The BC diagnosis occurred between January 2016 and March 2018 at 23 institutions in Brazil.
Article Synopsis
- Stage III NSCLC accounts for about one-third of lung cancer cases, but detailed data on its distribution and treatment in Brazil is lacking.
- A study, RELANCE/LACOG 0118, analyzed 403 patients with stage III NSCLC across 13 cancer centers, focusing on their demographics, treatment, and survival outcomes from 2015 to 2021.
- Results show that patients with public health insurance face later diagnoses and worse overall survival, indicating a need for improved health policies to ensure timely diagnosis and access to treatment in Brazil.*
Moderately hypofractionated post-operative radiation therapy for breast cancer: preferences amongst radiation oncologists from countries in Latin America and the Caribbean.
Rep Pract Oncol Radiother
July 2023
Background: The safety and effectiveness of moderately hypofractionated post-operative radiation therapy for breast cancer were demonstrated by several trials. This study aimed to evaluate the current patterns of practice and prescription preference about moderately hypofractionated post-operative radiation therapy to assess possible aspects that affect the decision-making process regarding the use of fractionation in breast cancer patients in Latin America and the Caribbean (LAC). We also aimed to identify factors that can restrain the utilization of moderately hypofractionated post-operative radiation therapy for breast cancer.
View Article and Find Full Text PDFTime interval between diagnosis to treatment of breast cancer and the impact of health insurance coverage: a sub analysis of the AMAZONA III Study (GBECAM 0115).
Breast Cancer Res Treat
February 2023
Purpose: Breast cancer (BC) is the most common type of cancer among women in Brazil. Evidence shows that delayed treatment onset is associated with increased mortality. This study aimed to evaluate median days between diagnosis and treatment and factors associated with delayed start of treatment (> 60 days after diagnosis): stage, treatment received, subtype, epidemiological characteristics, and type of healthcare coverage.
View Article and Find Full Text PDFBackground: Healthy lifestyle is capable of positively modifying the survival of breast cancer (BC) patients. We aimed to evaluate how physician's lifestyle influences on the prescription of healthy habits to BC patients.
Methods: An online questionnaire to evaluate physician lifestyle and prescription of healthy habits to BC patients was developed and circulated by e-mail to physicians dedicated to treat BC patients.
A phase 2 randomized clinical trial of abiraterone plus ADT, apalutamide, or abiraterone and apalutamide in patients with advanced prostate cancer with non-castrate testosterone levels (LACOG 0415).
Eur J Cancer
October 2021
Background: Androgen deprivation therapy (ADT) combined with apalutamide, abiraterone acetate plus prednisone, enzalutamide, or docetaxel are the standard treatments for advanced castration-sensitive prostate cancer (CSPC). We investigated ADT-free alternatives for advanced CSPC.
Patients And Methods: LACOG 0415 is a phase 2, open-label, non-comparative, randomized trial.
The impact of sociodemographic factors and health insurance coverage in the diagnosis and clinicopathological characteristics of breast cancer in Brazil: AMAZONA III study (GBECAM 0115).
Breast Cancer Res Treat
October 2020
Article Synopsis
- In Brazil, cancer registries are lacking, leading to insufficient data about breast cancer patients' characteristics and outcomes, which prompted the AMAZONA III study to better understand these factors.
- The study included 2,950 women diagnosed with invasive breast cancer between January 2016 and March 2018, examining their health insurance type and disease stage at diagnosis.
- Results showed that publicly insured patients typically had later-stage cancer and were more frequently diagnosed through symptoms, while privately insured patients were more likely to have earlier-stage disease and were often diagnosed through screening.