Publications by authors named "Rafaela Fintelman Rodrigues"
Despite the fact that the peripheral nervous system is able to regenerate after traumatic injury, the functional outcomes following damage are limited and poor. Bone marrow mesenchymal stem cells (MSCs) are multipotent cells that have been used in studies of peripheral nerve regeneration and have yielded promising results. The aim of this study was to evaluate sciatic nerve regeneration and neuronal survival in mice after nerve transection followed by MSC treatment into a polycaprolactone (PCL) nerve guide.
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- Researchers are exploring ways to improve spinal cord regeneration after injury, focusing on cell-based therapies, particularly human dental pulp cells (HDPCs).
- In a study involving mice with spinal cord injuries, HDPCs were transplanted at different times post-injury to assess recovery effects.
- Results indicated that HDPCs led to better tissue preservation, enhanced expression of beneficial factors, improved organization, increased myelination of axons, and functional locomotor improvements, suggesting HDPCs could be a promising treatment for spinal cord injuries.