Cyclin E/CDK2: DNA Replication, Replication Stress and Genomic Instability.

DNA replication must be precisely controlled in order to maintain genome stability. Transition through cell cycle phases is regulated by a family of Cyclin-Dependent Kinases (CDKs) in association with respective cyclin regulatory subunits. In normal cell cycles, E-type cyclins (Cyclin E1 and Cyclin E2, and genes) associate with CDK2 to promote G1/S transition.