Exploring novel pyrazole-nitroimidazole hybrids: Synthesis and antiprotozoal activity against the human pathogen trichomonas vaginalis.

Trichomoniasis, a prevalent sexually transmitted infection (STI) caused by the protozoan Trichomonas vaginalis, has gained increased significance globally. Its relevance has grown in recent years due to its association with a heightened risk of acquiring and transmitting the human immunodeficiency virus (HIV) and other STIs. In addition, many publications have revealed a potential link between trichomoniasis and certain cancers.

Evaluation of fatigue and quality of life of colorectal cancer patients in chemotherapy.

Objective: To evaluate fatigue and health-related quality of life of colorectal cancer patients undergoing chemotherapy.

Method: Descriptive study conducted with 69 patients between January and September/2019 in a public hospital in Minas Gerais. Instruments used: sociodemographic and clinical questionnaire, Quality of Life Questionnaire-Core30 and Piper Fatigue Scale, analyzed according to measures of frequency, mean and standard deviation by the software PSPP.

A grey zone for bibliometrics: publications indexed in Web of Science as anonymous.

Unlabelled: Publications without authorship information have been indexed as anonymous in the Web of Science database over the years. However, discussions on this subject have not been sufficiently addressed in the scholarly literature. Since bibliometrics studies are widely used for bibliometricians, scientific disciplines, science policy, and management, missing significant data as authorship metadata characterizes a gray zone that directly impacts these three components, and by extension, for bibliometrics and scientometrics.

Structural Optimization and Biological Activity of Pyrazole Derivatives: Virtual Computational Analysis, Recovery Assay and 3D Culture Model as Potential Predictive Tools of Effectiveness against .

Chagas disease, a chronic and silent disease caused by , is currently a global public health problem. The treatment of this neglected disease relies on benznidazole and nifurtimox, two nitroheterocyclic drugs that show limited efficacy and severe side effects. The failure of potential drug candidates in Chagas disease clinical trials highlighted the urgent need to identify new effective chemical entities and more predictive tools to improve translational success in the drug development pipeline.

Cooperative behavior and management of a patient care team in an oncohematology hospital service.

Objective: to identify the perceptions of teamwork according to professionals of an oncohematology unit.

Methods: this is an exploratory study/qualitative approach. Nineteen health professionals from the oncohematology unit of a public teaching hospital participated.

Antioxidant activity and development of one chromatographic method to determine the phenolic compounds from Agroindustrial Pomace.

A chromatographic method consisting of multi wavelength detection for identification of six phenolic acids, one stilbene and five flavonoids in grape and apple pomaces was proposed. Scavenging of DPPH (2,2-diphenyl-1-picrylhydrazyl), ABTS (2,2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid), reactive oxygen species and reduction of Fe3+ to Fe2+ using in vitro and HPLC-UV-ABTS on-line methods are herein presented. A reversed phase C18 coupled with an absorption detector operating at 280, 300, 320 and 360 nm for the benzoic acid derivatives and flavanols; stilbenes; cinnamic acid derivatives and flavonols, were respecctively used.

Profile of audiometric thresholds and tympanometric curve of elderly patients.

Aim: to analyze the audiological profile of elderly patients seen in a clinic from an audiology school clinic in the city of Belo Horizonte.

Methods: we studied all the charts from the patients who underwent audiologic assessment from April of 2004 and August of 2007 in an audiology clinic in the city of Belo Horizonte.

Results: We studied the 313 audiological tests from patients 60 years of age or over.