The contamination of seas, rivers, lakes, and groundwater by industrial, hospital, and domestic effluents is a global health problem. Scientific approaches are needed to assess and mitigate the impacts of those pollutants, seeking more sustainable alternatives that meet established environmental standards. Among the various contaminants that are released into water sources, phenobarbital (PHEN), a long-acting barbiturate, applied as a hypnotic, sedative, and in the treatment of seizures is an aquatic pollutant, raises significant concerns for human health and the environment.
View Article and Find Full Text PDFStatins are hypocholesterolemic drugs that are prescribed for patients with an increased risk of cardiovascular and cerebrovascular complications. Ezetimibe has an atheroprotective activity through inhibition of the expression of vascular adhesion molecule-I and vascular CD14, a marker of the infiltration of mononuclear leukocytes. Ezetimibe reduces the amount of chemoattractant protein-1 that is available for monocytes and macrophages and alters the activity of nuclear factor κB in leukocytes.
View Article and Find Full Text PDFFish oil, a rich source of n-3 fatty acids, has been studied for its beneficial effects in many diseases. Recent studies have shown the robust anti-inflammatory activity of fish oil (FO), when administered orally to rats, in models of acute inflammation. Herein, we investigated if treatment with fish oil preparation (FOP) could interfere with the recruitment of leukocytes into the joint cavity of arthritic rats.
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