Protein tyrosine phosphatase 1B inhibitory activity of compounds from Justicia spicigera (Acanthaceae).

An infusion from the aerial parts of Justicia spicigera Schltdl., an herb commonly used to treat diabetes, inhibited the activity of protein tyrosine phosphatase 1B (PTP1B). Two undescribed compounds, 2-N-(p-coumaroyl)-3H-phenoxazin-3-one, and 3″-O-acetyl-kaempferitrin, along with kaempferitrin, kaempferol 7-O-α-L-rhamnopyranoside, perisbivalvine B and 2,5-dimethoxy-p-benzoquinone were isolated from the active extract.

α-Glucosidase Inhibitors from .

Fractionation of an aqueous extract from the aerial parts of yielded a new natural product, namely, 4-hydroxy-3-(()-1'-angeloyloxy-()-2',3'-epoxy-3'-methyl)butylacetophenone (), along with eight known compounds, including three flavonoids (-) and five chromenes (-). NMR data interpretation and DFT-calculated chemical shifts combined with DP4+ statistical and -DP4 probability analyses allowed for the complete characterization of compound . The presence of compound in a plant that biosynthesizes 2,2-dimethylchromenes is noteworthy, because an epoxy derivative has long been postulated as the reaction intermediate from the prenylated -hydroxyacetophenones to cyclic dimethylchromenes.

Antinociceptive Effect of an Aqueous Extract and Essential Oil from .

Infusions and poultices prepared from the aerial parts of Kunth (Asteraceae) are widely used in Oaxaca (Mexico) for relieving painful and inflammatory complaints. Therefore, the antinociceptive potential of an aqueous extract (31.6-316 mg/kg, p.

Flavonoids and Terpenoids with PTP-1B Inhibitory Properties from the Infusion of Ortega.

An infusion prepared from the aerial parts of Ortega inhibited the enzyme protein tyrosine phosphatase 1B (PTP-1B) (IC~88 and 33 μg/mL, respectively). Phytochemical analysis of the infusion yielded amarisolide (), 5,6,4'-trihydroxy-7,3'-dimethoxyflavone (), 6-hydroxyluteolin (), rutin (), rosmarinic acid (), isoquercitrin (), pedalitin () and a new -clerodane type diterpenoid glucoside, named amarisolide G (,). Compound , is a new natural product, and - are reported for the first time for the species.