Publications by authors named "Rafael Soares Nunes Pinheiro"
Purpose: Gene expressions of vascular Endothelial Growth Factor Alpha (VEGFa), Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B cells (NFkB) and cytokines could be useful for identifying potential therapeutic targets to alleviate ischemia-reperfusion injury after liver transplantation. Cytokine gene expressions, VEGFa and NFkB were investigated in a preclinical swine model of liver transplantation.
Methods: A total of 12 pigs were used as donors and recipients in liver transplantation without venovenous bypass or aortic clamping.
Article Synopsis
- Intrahepatic cholangiocarcinoma (iCC) is a serious liver disease and surgery is the only way to cure it, but not many patients can have surgery right away.
- This study looked at using living donor liver transplants (LDLT) as a treatment for iCC, including a special case of a patient whose cancer couldn’t be removed by surgery.
- While using liver transplants for this cancer used to have bad results, now it seems to be a better option, especially for certain patients, even though there are still not enough organ donors available.
Background: Perihilar cholangiocarcinoma (phCCC) is a dismal malignancy. There is no consensus regarding the best treatment for patients with unresectable phCCC. The present review aimed to gather the current pieces of evidence for liver transplantation and liver resection as a treatment for phCCC and to build better guidance for clinical practice.
View Article and Find Full Text PDFIntrahepatic cholangiocarcinoma (ICC) is a relatively uncommon but highly aggressive primary liver cancer that originates within the liver. The aim of this study is to review the molecular profile of intrahepatic cholangiocarcinoma and its implications for prognostication and decision-making. This comprehensive characterization of ICC tumors sheds light on the disease's underlying biology and offers a foundation for more personalized treatment strategies.
View Article and Find Full Text PDFObjective Tumor Response of Hepatocellular Carcinoma Obtained by Transarterial Radioembolization with Iodine-131-Lipiodol Versus Transarterial Chemoembolization for Patients with and without Portal Venous Thrombosis: A Controlled Interventional Trial.
Acad Radiol
May 2024
Rationale And Objectives: Hepatocellular carcinoma (HCC) treatment often requires transarterial chemoembolization (TACE). However, TACE efficacy is controversial in the presence of portal vein thrombosis (PVT). Although transarterial radioembolization (TARE) benefit was previously documented in PVT, neither the objective tumor response (OTR) after TARE with Iodine-131-lipiodol (I-lipiodol) nor the PVT effect on the results of locoregional therapies was accurately measured in prospective clinical trials.
View Article and Find Full Text PDFBackground: Surgery is the only potentially curative treatment for colorectal cancer liver metastases (CRLMs). Despite an improvement in results following resection, recurrence rates remain high. Many histopathological features have been reported as prognostic factors.
View Article and Find Full Text PDFThis study reports a patient with DRESS syndrome, associated with liver failure, treated with orthotopic liver transplantation.
View Article and Find Full Text PDFA POSSIBLE COMPLICATION AFTER LIVER TRANSPLANTATION IN A GASTRIC BYPASS BARIATRIC PATIENT: DON'T FORGET THE EXCLUDED STOMACH! CASE REPORT AND REVIEW OF THE LITERATURE.
Arq Bras Cir Dig
August 2020
Background: Traditionally, elective abdominal procedures in cirrhotic patients have been largely discouraged due to high morbidity and mortality consequent to complications of cirrhosis, described by several authors. Other services, however, obtained different results, advocating in favor of elective surgery.
Methods: A literature review using as key-words "abdominal wall hernia" and "cirrhotic patients" was performed using PubMed database.