Assessing the impact of different urban morphology scenarios on air pollutant emissions distribution.

As urban areas grow with the increase in population, so do the problems associated with these areas, such as an increase in atmospheric emissions. Since urban morphology has an effect on the environment, it is necessary to design future urban morphologies to accommodate the expected growth and mitigate the associated problems. By employing an emission distribution methodology based on the relationship between land use and emission activity sectors, including transport and road traffic emissions modelling (with PTV-VISUM and TREM, respectively), this study aims to identify urban morphologies that have the potential to minimize atmospheric emissions for future multi-core regions.

Discovery and Mechanistic Elucidation of NQO1-Bioactivatable Small Molecules That Overcome Resistance to Degraders.

Degraders hold the promise to efficiently inactivate previously intractable disease-relevant targets. Unlike traditional inhibitors, degraders act substoichiometrically and rely on the hijacked proteolysis machinery, which can also act as an entry point for resistance. To fully harness the potential of targeted protein degradation, it is crucial to comprehend resistance mechanisms and formulate effective strategies to overcome them.

High-resolution multi-scale air pollution system: Evaluation of modelling performance and emission control strategies.

A high percentage of the world's population lives in areas where air pollutant concentrations exceed the World Health Organization guidelines. This work aims to develop and test, a high-resolution multi-scale air pollution modelling system by integrating a set of adequate tools. This system is able to provide detailed air pollutant concentrations in urban areas and support air quality management strategies through a better identification of different atmospheric processes.

An integrated analysis of COVID-19 impacts on energy and environment: Lessons learnt.

Carbon neutrality, sustainable development and reducing our impact on the environment is the top priority in future measures. The COVID-19 pandemic brought challenges to every sector at a global scale but can provide valuable insight to reach these goals. The main objective of this work is to provide an integrated analysis of the impact of the COVID-19 pandemic, focused on energy and its related aspects, i.

How well have CMIP3, CMIP5 and CMIP6 future climate projections portrayed the recently observed warming.

Despite the dire conclusions of the Intergovernmental Panel on Climate Change (IPCC) Assessment Reports in terms of global warming and its impacts on Earth's climate, ecosystems and human society, a skepticism claiming that the projected global warming is alarmist or, at least, overestimated, still persists. Given the years passed since the future climate projections that served as basis for the IPCC 4th, 5th and 6th Assessment Reports were released, it is now possible to answer this fundamental question if the projected global warming has been over or underestimated. This study presents a comparison between CMIP3, CMIP5 and CMIP6 future temperature projections and observations.

How can the built environment affect the impact of autonomous vehicles' operational behaviour on air quality?

Autonomous vehicles (AVs) are pointed out as the technology that will reshape the concept of mobility, with significant implications for the economy, the environment, and society. This fact will bring new challenge to cities urban planning. Research to anticipate the AVs impacts, maximizing their benefits and reduce trade-offs are currently crucial.

'We go where we know': Reflections from Mobilizing for PrEP and Sexual Health (MobPrESH) - A peer-led PrEP education programme across England, for and by women and non-binary people.

Background: Pre-exposure prophylaxis is a highly effective method of HIV prevention but few women know about it, have access to it, or see it as relevant to them. In 2019, grassroots organization PrEPster piloted a peer-led intervention, MobPrESH (Mobilizing for Pre-Exposure prophylaxis (PrEP) and Sexual Health), across three sites in England, to mobilize for PrEP and sexual health with communities of women and non-binary people most affected by HIV, including Black women and non-binary people, people of colour, migrants, and transgender (trans) women.

Objectives: We aimed to explore the accessibility, feasibility, acceptability, and 'fidelity' of MobPrESH, from the perspectives of peer mobilizers and project staff.

Two new species of Elachistocleis Parker, 1927 (Anura: Microhylidae: Gastrophryninae) from Colombia.

The genus Elachistocleis consists of small to medium size species of Neotropical microhylids. It is the second largest genus of New World microhylids and an important component of the anuran diversity in the Neotropical region. Herein, based on morphological, acoustical, and molecular evidence, we describe two new species and their advertisement calls.

Qualitative findings from : a social media application of the Sabido methodology for sexual health and HIV prevention in the United Kingdom.

The health communication strategy known as entertainment-education can be traced in large part to Miguel Sabido and the methodology he developed using telenovelas in Latin America in the 1960s and 1970s. Entertainment-education has evolved from a long-running narrative approach using traditional media to the addition of new media and transmedia formats. In recent years, entertainment-education programs using social media have increased, yet few studies have explored the shared characteristics and experiences of social media users who engage with these programs.

Assessing the impacts of citizen-led policies on emissions, air quality and health.

Air pollution is a global challenge, and especially urban areas are particularly affected by acute episodes. Traditional approaches used to mitigate air pollution primarily consider the technical aspects of the problem but not the role of citizen behaviour and day-to-day practices. ClairCity, a Horizon 2020 funded project, created an impact assessment framework considering the role of citizen behaviour to create future scenarios, aiming to improve urban environments and the wellbeing and health of its inhabitants.

Are green roofs the path to clean air and low carbon cities?

Green roofs, as part of urban green structures, have been pointed out as the solution to pursuit the goal of healthy cities. This study aims to investigate the direct, focused on meteorological changes, and indirect, related to both meteorological and emissions changes, impacts of green roofs on air quality (PM10, NO and O). For that, the numerical modelling system composed by the WRF-SLUCM-CHIMERE models was applied to a 1-year period (2017), having as case study the Porto urban area.

How to compute long-term averages for air quality assessment at urban areas?

This paper proposes two innovative time-effective approaches to retrieve annual averaged concentrations for air quality assessment in the framework of the AQD. In addition, a traditional method (M1) was applied through numerical simulations for an entire year on an hourly basis to compare the performance of the proposed approaches. The first time-effective approach (M2) is based on the calculation of pollutant concentrations for the full year on an hourly basis through the combination of a set of numerical simulations for 4 typical days weighted by hourly factors obtained from air quality monitoring data.

In Vitro Development of a New Sponge-Based Delivery System for Intracanal Antimicrobial Administration in Endodontic Treatment.

This study aimed to evaluate the in vitro performance of collagen-based sponges as a drug delivery system for intracanal antimicrobial administration. Four groups of loaded collagen-based sponges (A, 0.3% / amoxicillin trihydrate: potassium clavulanate (4:1); B, 0.

Analysis of spatial factors, time-activity and infiltration on outdoor generated PM exposures of school children in five European cities.

Atmospheric particles are a major environmental health risk. Assessments of air pollution related health burden are often based on outdoor concentrations estimated at residential locations, ignoring spatial mobility, time-activity patterns, and indoor exposures. The aim of this work is to quantify impacts of these factors on outdoor-originated fine particle exposures of school children.

Missed opportunities for sexually transmitted infections testing for HIV pre-exposure prophylaxis users: a systematic review.

Introduction: Given the synergistic relationship between HIV and sexually transmitted infections (STI), the integration of services has the potential to reduce the incidence of both HIV and STIs. We explored the extent to which STI testing has been offered within HIV pre-exposure prophylaxis (PrEP) programmes worldwide.

Methods: We conducted a systematic review of PrEP programmes implementing STI testing services in nine databases.

How changing climate may influence air pollution control strategies for 2030?

Air pollution is a global threat leading to large impacts on human health and ecosystems. In Europe, air quality remains poor in many areas, despite reductions in emissions and ambient concentrations. Air pollution and climate change are the biggest environmental concerns for Europeans, implying concerted and integrated actions to tackle them.

Arthroscopically Assisted Comprehensive Double Cerclage Suture Fixation Technique for Acute Acromioclavicular Joint Separation.

Acromioclavicular dislocations are some of the most frequently recorded and controversial injuries in the athletic population. These injuries have historically been a matter of disagreement between surgeons, particularly when it comes to the surgical technique used to treat them, its approach, or its timing. Consensus over the "gold standard" procedure to treat them is yet to be established.

Modelling air quality levels of regulated metals: limitations and challenges.

Toxic metals as arsenic (As), cadmium (Cd), nickel (Ni), and lead (Pb) exist in the atmosphere as particulate matter components. Their concentration levels in the European Union (EU) are regulated by European legislation, which sets target and limit values as annual means, and by the World Health Organization (WHO) that defines guidelines and reference values for those metal elements. Modelling tools are recommended to support air quality assessment regarding the toxic metals; however, few studies have been performed and those assessments rely on discrete measurements or field campaigns.

Climate-Change Adaptation Framework for Multiple Urban Areas in Northern Portugal.

Climate change is increasingly exerting pressure with intensified impacts in the short-, medium-, and long-term. Cities are highly vulnerable to the impacts of climate change, and it is recognized that they play a significant role in the European Strategy on adaptation to climate change. This study intends to develop a climate adaptation framework to identify effective measures that will be evaluated using a multi-urban area located in the north of Portugal, as a case study.

New haematologic score to discriminate beta thalassemia trait from iron deficiency anaemia in a Spanish Mediterranean region.

Several studies have stablished discriminant formulas (DF) from red blood cell (RBC) data as simple, low time-consuming and inexpensive tools to differentiate β-thalassemia trait (β-TT) from iron deficiency anaemia (IDA). The aim of this work is to introduce new formulas and evaluate them in the differentiation of microcytic anaemia (MA) into either β-TT or IDA in the Mediterranean region of Tarragona. A total of 200 anonymized haematological determinations with MA were collected, 100 diagnosed of β-TT and 100 diagnosed of IDA.

Autonomous vehicles opportunities for cities air quality.

The impacts of autonomous vehicles (AV) on safety, energy and atmospheric emissions have been recognised to be important issues, but an air quality impact assessment is missing. In this study, by using a numerical modelling approach, the impact of AV on the air quality of a medium-sized Portuguese urban area was evaluated. For that, the air pollutants nitrogen oxides (NOx) and carbon dioxide (CO) were considered and three scenarios were developed: i) a baseline scenario; ii) an autonomous scenario, assuming an AV market penetration rate of 30%; and iii) an electric autonomous scenario, taking into account that those 30% of AV are pure battery electric cars.

Catalytic Regioselective Isomerization of 2,2-Disubstituted Oxetanes to Homoallylic Alcohols.

The selective isomerization of strained heterocyclic compounds is an important tool in organic synthesis. An unprecedented regioselective isomerization of 2,2-disubstituted oxetanes into homoallylic alcohols is described. The use of tris(pentafluorophenyl)borane (B(C F ) ) a commercially available Lewis acid was key to obtaining good yields and selectivities since other Lewis acids afforded mixtures of isomers and substantial polymerization.

Global Epidemiologic Characteristics of Sexually Transmitted Infections Among Individuals Using Preexposure Prophylaxis for the Prevention of HIV Infection: A Systematic Review and Meta-analysis.

Importance: Despite a global increase in sexually transmitted infections (STIs), there is limited focus and investment in STI management within HIV programs, in which risks for STIs are likely to be elevated.

Objective: To estimate the prevalence of STIs at initiation of HIV preexposure prophylaxis (PrEP; emtricitabine and tenofovir disoproxil fumarate) and the incidence of STIs during PrEP use.

Data Sources: Nine databases were searched up to November 20, 2018, without language restrictions.

Clinical and tomographic comparison of dental implants placed by guided virtual surgery versus conventional technique: A split-mouth randomized clinical trial.

Aim: Our objective was to compare guided virtual surgery to conventional surgery in terms of angular deviation of single dental implants placed in the posterior mandible.

Materials And Methods: Patients with bilateral homologous single teeth missing in the posterior mandible were eligible for this split-mouth randomized clinical trial. Cone beam computed tomography (CBCT) was performed for virtual planning of implant position and manufacturing of the stereolithographic guides.