CLARUS as a Cloud Security Framework: e-Health Use Case.

Maintaining Passive Medical Health Records (PMHR) is an increasing cost and resource consumption problem. Moving to the cloud is the clearest solution to solve the problem as it offers a high amount of space and computation power. But the cloud is not safe enough when dealing with this kind of information because it can be easily accessed by attackers.

Low aspect ratio micropores for single-particle and single-cell analysis.

This paper describes microparticle and bacterial translocation studies using low aspect ratio solid-state micropores. Micropores, 5 μm in diameter, were fabricated in 200 nm thick free-standing silicon nitride membranes, resulting in pores with an extremely low aspect ratio, nominally 0.04.

Chemically modified solid state nanopores for high throughput nanoparticle separation.

The separation of biomolecules and other nanoparticles is a vital step in several analytical and diagnostic techniques. Towards this end we present a solid state nanopore-based set-up as an efficient separation platform. The translocation of charged particles through a nanopore was first modeled mathematically using the multi-ion model and the surface charge density of the nanopore membrane was identified as a critical parameter that determines the selectivity of the membrane and the throughput of the separation process.

Ultra-fast low concentration detection of Candida pathogens utilizing high resolution micropore chips.

Although Candida species are the fourth most common cause of nosocomial blood stream infections in the United States, early diagnostic tools for invasive candidemia are lacking. Due to an increasing rate of candidemia, a new screening system is needed to detect the Candida species in a timely manner. Here we describe a novel method of detection using a solid-state micro-scale pore similar to the operational principles of a Coulter counter.

Single-molecule spectroscopy using nanoporous membranes.

We describe a novel approach for optically detecting DNA translocation events through an array of solid-state nanopores that potentially allows for ultra high-throughput, parallel detection at the single-molecule level. The approach functions by electrokinetically driving DNA strands through sub micrometer-sized holes on an aluminum/silicon nitride membrane. During the translocation process, the molecules are confined to the walls of the nanofluidic channels, allowing 100% detection efficiency.