Publications by authors named "Rafael Lima Rodrigues Carvalho"
Characteristics and outcomes of in-hospital patients with Covid-19 and history of tuberculosis: a matched case-control from the Brazilian Covid-19 Registry.
BMC Infect Dis
December 2024
Article Synopsis
- The Covid-19 pandemic adversely affected the management of other infectious diseases, especially in low and middle-income countries, leading to concerns about diseases like tuberculosis.
- A matched case-control study compared Covid-19 effects in patients with prior tuberculosis against those without, using data from Brazilian hospitals over two years.
- Results showed the tuberculosis group had higher rates of several comorbidities and medication usage but did not experience more severe outcomes like higher in-hospital mortality or need for intensive care compared to the control group.
Context: COVID-19 induces complex distress across physical, psychological, and social realms and palliative care (PC) has the potential to mitigate this suffering significantly.
Objectives: To describe the clinical characteristics and outcomes of COVID-19 patients with an indication of PC, compared to patients who had no indication, in different pandemic waves.
Methods: This retrospective multicenter observational cohort included patients from 40 hospitals, admitted from March 2020 to August 2022.
Correction: Development and validation of the MMCD score to predict kidney replacement therapy in COVID-19 patients.
BMC Med
June 2023
Potential and limitations of machine meta-learning (ensemble) methods for predicting COVID-19 mortality in a large inhospital Brazilian dataset.
Sci Rep
March 2023
The majority of early prediction scores and methods to predict COVID-19 mortality are bound by methodological flaws and technological limitations (e.g., the use of a single prediction model).
View Article and Find Full Text PDFDevelopment and validation of the MMCD score to predict kidney replacement therapy in COVID-19 patients.
BMC Med
September 2022
Article Synopsis
- - The study investigated acute kidney injury (AKI) in hospitalized COVID-19 patients, focusing on predicting the need for kidney replacement therapy (KRT) as a measure of disease severity.
- - Researchers used a large cohort of 5212 adult patients, employing statistical methods like generalized additive models and LASSO regression to develop a prognostic score named MMCD, identifying four key predictors for KRT.
- - The MMCD score demonstrated high accuracy in predicting KRT requirements across various cohorts and is accessible via an online risk calculator, potentially aiding healthcare professionals in managing COVID-19 patients.
Around 5% of coronavirus disease 2019 (COVID-19) patients develop critical disease, with severe pneumonia and acute respiratory distress syndrome (ARDS). In these cases, extracorporeal membrane oxygenation (ECMO) may be considered when conventional therapy fails. This study aimed to describe the clinical characteristics and in-hospital outcomes of COVID-19 patients with ARDS refractory to lung-protective ventilation and prone positioning on ECMO support, as well as to review the available literature on ECMO use and COVID-19 patients' outcome.
View Article and Find Full Text PDFChagas disease and SARS-CoV-2 coinfection does not lead to worse in-hospital outcomes.
Sci Rep
October 2021
Chagas disease (CD) continues to be a major public health burden in Latina America. Information on the interplay between COVID-19 and CD is lacking. Our aim was to assess clinical characteristics and in-hospital outcomes of patients with CD and COVID-19, and to compare it to non-CD patients.
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