Assessment of Reproducibility and Agreement of the IDEAL Classification for Distal Radius Fractures.

 To analyze the reproducibility and intra- and interobserver agreement of the IDEAL classification for distal radius fractures.  This qualitative, analytical study evaluated 50 pairs of radiographs in two views of patients with distal radius fractures. There were ten observers with different levels of orthopedic training who assessed the radiographs in three different evaluations.

Potent nonopioid antinociceptive activity of telocinobufagin in models of acute pain in mice.

Introduction: In recent decades, several researches have been conducted in search of new analgesics that do not present the side effects of opioids. In this context, animal venoms contain natural painkillers that have been used for the development of new analgesics.

Objective: The aims of this study were to evaluate the antinociceptive effects of telocinobufagin (TCB), a bufadienolide isolated from venom, in murine acute pain models, and to verify the participation of the opioid system in these effects.