Publications by authors named "Rafael Hospodar Felippe Valverde"
Sphingosine 1-phosphate protective effect on human proximal tubule cells submitted to an in vitro ischemia model: the role of JAK2/STAT3.
J Physiol Biochem
November 2024
Article Synopsis
- * Understanding the underlying mechanisms of AKI is crucial for developing effective treatments, particularly focusing on cell rescue and paracrine factors that aid in tissue repair.
- * In this study, sphingosine 1-phosphate (S1P) was found to significantly enhance cell survival and proliferation in kidney proximal tubule cells after I/R injury, demonstrating its potential in promoting tissue repair via specific signaling pathways, including the SAFE and JAK2/STAT3 pathways.
Purpose: The clinical outcomes of kidney transplantation from deceased donors have seen significant improvements with the use of machine perfusion (MP), now a standard practice in transplant centers. However, the use of perfusate biomarkers for assessing organ quality remains a subject of debate. Despite this, some centers incorporate them into their decision-making process for donor kidney acceptance.
View Article and Find Full Text PDFBackground: The effect of mercury (Hg(2+)) on the activity of choline acetyltransferase (ChAT) from electrocytes of Electrophorus electricus (L.) was studied due to the importance of this enzyme and acetylcholine in many neurochemical functions such as arousal, learning, and memory.
Material/methods: Mercury, which has affinity to thiol groups, acted as a potent inhibitor of ChAT, which was obtained by differential centrifugation and ammonium sulfate precipitation, at 80%, from the main electric organ homogenate.