Publications by authors named "Rafael Gras-Pena"
BACKGROUNDIt is unknown whether the risk of kidney disease progression and failure differs between patients with and without genetic kidney disorders.METHODSThree cohorts were evaluated: the prospective Cure Glomerulonephropathy Network (CureGN) and 2 retrospective cohorts from Columbia University, including 5,727 adults and children with kidney disease from any etiology who underwent whole-genome or exome sequencing. The effects of monogenic kidney disorders and APOL1 kidney-risk genotypes on the risk of kidney failure, estimated glomerular filtration rate (eGFR) decline, and disease remission rates were evaluated along with diagnostic yields and the impact of American College of Medical Genetics secondary findings (ACMG SFs).
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- This study focuses on creating human thymic epithelial progenitors from human embryonic stem cells to address conditions related to thymic insufficiency.
- The researchers used specific growth factors to differentiate these stem cells and tested their ability to support T-cell development in mouse models with hybrid thymus implants.
- The results showed that the generated thymic progenitors effectively promoted human T-cell development and improved immune function, highlighting the potential for new therapies using this technique.