Newborn auditory brainstem response and sudden infant death syndrome.

Sudden infant death syndrome (SIDS)-the sudden and unexplained death of a seemingly healthy infant, <1 year old-may be associated with abnormalities in the brain regions that underlie breathing and arousal during sleep. While post-mortem studies suggest abnormalities in SIDS infants' brainstems, there are no studies of these infants' brainstem function before death. One way to assess the function of the brainstem is with auditory brainstem response (ABR), a routine hearing-screening method that noninvasively measures the brainstem's response to sound.

Quick Estimation of Minimum Hearing Levels Using a Binaural Multifrequency Stimulus Paradigm: Proof of Concept.

Objectives: Objective estimation of minimum hearing levels using auditory brainstem responses (ABRs) elicited by single frequency tone-bursts presented monaurally is currently considered the gold standard. However, the data acquisition time to estimate thresholds (for both ears across four audiometric frequencies) using this method usually exceeds the sleep time (ranging between 35 and 49 minutes) in infants below 4 months, thus providing incomplete information of hearing status which in turn delays timely clinical intervention. Alternate approaches using faster rate, or tone-burst trains have not been readily accepted due to additional hardware and software requirements.

Sensing echoes: temporal misalignment in auditory brainstem responses as the earliest marker of neurodevelopmental derailment.

Neurodevelopmental disorders are on the rise worldwide, with diagnoses that detect derailment from typical milestones by 3 to 4.5 years of age. By then, the circuitry in the brain has already reached some level of maturation that inevitably takes neurodevelopment through a different course.

Skin-Tightening Devices (Radiofrequency) in Mixed-Race Patients.

Mixed-race patients seeking noninvasive esthetic procedures with minimal to no downtime are increasing, the most common issue in this group of patients when using medical technologies is post-inflammatory hyperpigmentation or hypopigmentation. Radiofrequency (RF) is an energy that is safe for treating all skin types because it does not interact target chromophore, its mechanism of action is the production of heat by shooting electrons into tissue and the interaction with that tissue's impedance or resistance is what produces the heat, and the heat induces collagen remodeling and collagenesis, so skin color, melanin, and hemoglobin do not play any role in RF-based treatments.

The Effects of Middle-ear Stiffness on the Auditory Brainstem Neural Encoding of Phase.

The middle-ear system relies on a balance of mass and stiffness characteristics for transmitting sound from the external environment to the cochlea and auditory neural pathway. Phase is one aspect of sound that, when transmitted and encoded by both ears, contributes to binaural cue sensitivity and spatial hearing. The study aims were (i) to investigate the effects of middle-ear stiffness on the auditory brainstem neural encoding of phase in human adults with normal pure-tone thresholds and (ii) to investigate the relationships between middle-ear stiffness-induced changes in wideband acoustic immittance and neural encoding of phase.

Newborn Auditory Brainstem Responses in Children with Developmental Disabilities.

We integrated data from a newborn hearing screening database and a preschool disability database to examine the relationship between newborn click evoked auditory brainstem responses (ABRs) and developmental disabilities. This sample included children with developmental delay (n = 2992), speech impairment (SI, n = 905), language impairment (n = 566), autism spectrum disorder (ASD, n = 370), and comparison children (n = 128,181). We compared the phase of the ABR waveform, a measure of sound processing latency, across groups.

Prolonged Auditory Brainstem Response in Universal Hearing Screening of Newborns with Autism Spectrum Disorder.

Previous studies report prolonged auditory brainstem response (ABR) in children and adults with autism spectrum disorder (ASD). Despite its promise as a biomarker, it is unclear whether healthy newborns who later develop ASD also show ABR abnormalities. In the current study, we extracted ABR data on 139,154 newborns from their Universal Newborn Hearing Screening, including 321 newborns who were later diagnosed with ASD.

Auditory brainstem, middle and late latency responses to short gaps in noise at different presentation rates.

Objective: The effects of rate on auditory-evoked potentials (AEP) to short noise gaps (12 ms) recorded at high sampling rates using wide-band filters were investigated.

Design: Auditory brainstem (ABR), middle latency (MLR), late latency (LLR) and steady-state (ASSR) responses were simultaneously recorded in adult subjects at four gap rates (0.5, 1, 5 and 40 Hz).

Human Summating Potential Using Continuous Loop Averaging Deconvolution: Response Amplitudes Vary with Tone Burst Repetition Rate and Duration.

Electrocochleography (ECochG) to high repetition rate tone bursts may have advantages over ECochG to clicks with standard slow rates. Tone burst stimuli presented at a high repetition rate may enhance summating potential (SP) measurements by reducing neural contributions resulting from neural adaptation to high stimulus repetition rates. To allow for the analysis of the complex ECochG responses to high rates, we deconvolved responses using the Continuous Loop Averaging Deconvolution (CLAD) technique.

Fast Click Rate Electrocochleography and Auditory Brainstem Response in Normal-Hearing Adults Using Continuous Loop Averaging Deconvolution.

Objectives: Using the continuous loop averaging deconvolution (CLAD) technique for conventional electrocochleography (ECochG) and auditory brainstem response (ABR) recordings, the effects of testing at high stimulus rates may have the potential to diagnose disorders of the inner ear and auditory nerve. First, a body of normative data using the CLAD technique must be established.

Design: Extratympanic click ECochG and ABR to seven stimulus rates using CLAD were measured simultaneously from a tympanic membrane electrode and surface electrodes on the forehead and mastoid of 42 healthy individuals.

The Effect of Stimulus Intensity and Carrier Frequency on Auditory Middle- and Long-Latency Evoked Potentials Using a Steady-State-Response Approach.

Purpose: The purpose of this study was to measure magnitude changes of auditory steady-state responses (ASSRs) and respective transient middle- and long-latency responses as a function of stimulus intensity and carrier frequency. The literature lacks clear consensus, including relationship to loudness.

Method: A cohort of 48 adults with normal hearing was examined from a companion study (Tlumak, Durrant, & Delgado, 2015) on effects of aging.

The Effect of Advancing Age on Auditory Middle- and Long-Latency Evoked Potentials Using a Steady-State-Response Approach.

Purpose: The purpose of the study was to objectively detect age-specific changes that occur in equivalent auditory steady-state responses (ASSRs), corresponding to transient middle- and long-latency auditory evoked potentials as a function of repetition rate and advancing age.

Method: The study included 48 healthy hearing adults who were equally divided into 3 groups by age: 20-39, 40-59, and 60-79 years. ASSRs were recorded at 7 repetition rates from 40 down to 0.

Clinical use of skull tap vestibular evoked myogenic potentials for the diagnoses of the cerebellopontine angle tumor patients.

Objective: To document our experiences using a new skull tapping induced Vestibular Evoked Myogenic Potentials (tap VEMPs) technique combined with standard Auditory Vestibular Evoked Myogenic Potentials (AC VEMPs) for advanced clinical assessment of cerebellopontine angle tumor (CPAT) patients.

Design And Study Sample: Three patients were selected in order to highlight observations shown in a larger patient population and to show the variability of the findings. Both tap VEMPs and AC VEMPs were acquired from the sternocleidomastoid muscle (SCM) with EMG-based biofeedback and monitoring.

Use of fractional laser in mixed-race patients.

The use of fractional lasers in mixed race patients has always been a challenge. Post-inflammatory hyperpigmentation or worsening of existing melasma is a risk and its presence can be unpredictable. The authors present their experience in patients with Fitzpatrick skin types IV to VI using fractional lasers.

Steady-state analysis of auditory evoked potentials over a wide range of stimulus repetition rates: profile in children vs. adults.

Objective: Auditory steady-state responses (ASSR) evoked by recurrent brief tones were assessed over a wide range of stimulus repetition rates apropos the traditionally measured obligatory, transient, auditory evoked potentials. Repetition rates of ≤ 10 Hz have received little attention in the context of the ASSR stimulus-response analysis approach, speculated to provide technical advantages/additional information over more traditional transient stimulus-response paradigms.

Design: Magnitudes were measured at repetition rates from 0.

Steady-state analysis of auditory evoked potentials over a wide range of stimulus repetition rates in awake vs. natural sleep.

Objective: Auditory steady-state responses (ASSR) evoked by recurrent tones were assessed over a wide range of stimulus repetition rates embracing well the traditionally measured transient AEPs. Repetition rates of ≤ 10 Hz have received little attention in the context of the ASSR stimulus-response analysis approach which is speculated to provide technical advantages, if not additional/supplemental information, over more traditional transient stimulus-response paradigms.

Design: Magnitudes were measured at repetition rates from 0.

Design of a clinically viable pneumatic system for the acquisition of pressure compensated otoacoustic emissions.

Otoacoustic emission (OAE) screening is perhaps one of the most common diagnostic tools used on both adults and children alike to clinically asses hearing health. However small to moderate middle ear pressures (both positive and negative), which are quite prevalent among the general population, are known to significantly reduce the OAE response specifically among frequencies below 2 kHz. This study focuses on the design and development of a software controlled syringe pump which will be used for the automatic compensation of middle ear pressure.

Steady-state analysis of auditory evoked potentials over a wide range of stimulus repetition rates: profile in adults.

Objective: Quasi-steady-state responses were assessed over a wide range of stimulus repetition rates embracing well the traditionally measured transient AEPs (obligatory auditory evoked potentials of all latencies). Repetition rates of ≤10 Hz have received little attention in the context of the ASSR stimulus-response analysis approach which is speculated to provide technical advantages, if not additional information, over more traditional transient stimulus-response paradigms.

Design: A measure introduced and defined as the sum of the response at the stimulus frequency and its harmonics.

Call for calibration standard for newborn screening using auditory brainstem responses.

The mode of stimulation employed in newborn screening of the auditory brainstem response has evolved from the clinically standardized supraaural earphone to the tubal insert earphone, to most recently a circumaural earphone developed for this test. Considered here is the need to develop a standard for calibration of such devices for newborn screening applications, in particular. At risk is the prospect of missing the milder degrees of hearing loss, assuming a goal of detecting all clinically-significant congenital hearing losses.

Audiometric threshold screening method using envelope detection filters of intensity ramping click auditory steady-state responses.

The Auditory Steady-state Responses (ASSR) elicited by click stimuli can be utilized for hearing screening as is traditionally done with click-evoked Auditory Brainstem Responses (ABR). In a typical ASSR or ABR hearing screening, several recordings at different intensities are required to find the response threshold. In this study the use of binaural click stimulus with time ramping intensity produces dual-ear evoked potentials in only one recording session, decreasing significantly the recording time.

Intraoperative monitoring of hearing during cerebellopontine angle tumor surgery using transtympanic electrocochleography.

Objective: To investigate the use of transtympanic electrocochleography (TT-ECochG) analyzed on-line by a detector strategy software that made possible automatic extraction of TT-ECochG components intraoperatively in real-time domain.

Patients: Fifteen patients with cerebellopontine angle tumor among 50 patients were included in this study.

Intervention: All subjects were operated on via middle fossa or retrosigmoid approach.

Simultaneous measurement of electrocochleography and cochlear blood flow during cochlear hypoxia in rabbits.

In this study, a new monitoring system is developed to measure cochlear blood flow (CBF) and electrocochleography (ECochG) during transient ischemic episodes of the cochlea. A newly designed otic probe was used for the simultaneous recordings of laser-Doppler CBF and ECochG directly from the round window (RW). The probe enabled the recording of high amplitude compound action potentials (CAP) and cochlear microphonics (CM) with few averages.

Neuromonitoring of cochlea and auditory nerve with multiple extracted parameters during induced hypoxia and nerve manipulation.

A system capable of comprehensive and detailed monitoring of the cochlea and the auditory nerve during intraoperative surgery was developed. The cochlear blood flow (CBF) and the electrocochleogram (ECochGm) were recorded at the round window (RW) niche using a specially designed otic probe. The ECochGm was further processed to obtain cochlear microphonics (CM) and compound action potentials (CAP).

Deconvolution of evoked responses obtained at high stimulus rates.

Continuous loop averaging deconvolution (CLAD) is a new general mathematical theory and method developed to deconvolve overlapping auditory evoked responses obtained at high stimulation rates. Using CLAD, arbitrary stimulus sequences are generated and averaged responses deconvolved. Until now, only a few special stimulus series such as maximum length sequences (MLS) and Legendre sequences (LGS) were capable of performing this task.

Evaluation of hearing and auditory nerve function by combining ABR, DPOAE and eABR tests into a single recording session.

In this article, we describe an efficient method for testing both auditory receptor and auditory nerve function in a single recording session. Auditory receptor function is tested in response to pure tone, tone burst and click acoustic stimuli (i.e.