The efficacy of topical insulin application on rat model with burn wounds treated with adipose-derived stem cells.

Overall, major burn wounds may require special care and long-term hospitalization as they not only bring complications from the wound itself, but may also compromise the immune system, or even other organs. Previous studies have indicated that topical insulin cream shortened wound closure time in second-degree burns in rats. Transplanted adipose-derived stem cells (AD-MSCs) have been developed as an alternative to treat burns and to accelerate the healing process.

Dexmedetomidine and Bupivacaine Association in Caudal Epidural Injection in Mares.

The objective of the study was to compare the effects of caudal epidural bupivacaine and dexmedetomidine (DEX) combination, with bupivacaine or DEX plain for perineal analgesia in mares. Six healthy saddle mares weighing 330-370 kg and aged 10-15 years were used in this study. Each mare was assigned to receive three treatments: 0.

Welfare and pregnancy rate of ewes undergoing transcervical artificial insemination with ketamine subarachnoid anesthesia.

This study aimed to evaluate the impact of subarachnoid anesthesia with ketamine during transcervical artificial insemination (TCAI) on the welfare of ewes and on subsequent pregnancy rates. Ninety Suffolk adult ewes were randomized into three treatment groups: control group (CG), which underwent the TCAI procedure as established by cervical traction (CG; n = 30) and two groups that received subarachnoid anesthesia with ketamine at a dose of either 0.75 mg/kg (KE0.

The effect of epidurally administered dexamethasone with lignocaine for post-operative analgesia in dogs undergoing ovariohysterectomy. A dose-response study.

Purpose:: To evaluate the postoperative analgesic and adverse effects of three doses of dexamethasone, administered epidurally in combination with lignocaine, in dogs undergoing ovariohysterectomy (OVH).

Methods:: Twenty-four female dogs undergoing ovariohysterectomy were pre-medicated with acepromazine and general anaesthesia was induced and maintained with propofol. Animals were randomly allocated into four groups of six.

Comparison between two different experimental models of osteoarthritis in rabbits. Intra-articular collagenase injection and anterior cruciate ligament transection.

Purpose:: To compare two different experimental models of osteoarthritis in rabbits: intra-articular collagenase injection and anterior cruciate ligament transection.

Methods:: Ten adult rabbits were randomly divided in two groups: COLL (collagenase group) and ACLT (anterior cruciate ligament transection). The COLL group was treated with 0.

Postoperative pain control in cats: clinical trials with pre-emptive lidocaine epidural co-administered with morphine or methadone.

Objectives The aim of the study was to evaluate the effectiveness of epidural lidocaine in combination with either methadone or morphine for postoperative analgesia in cats undergoing ovariohysterectomy. Methods Under general anesthesia, 24 cats that underwent ovariohysterectomy were randomly allocated into three treatment groups of eight each. Treatment 1 included 2% lidocaine (4.

Potentiation of epidural lidocaine by co-administering tramadol by either intramuscular or epidural route in cats.

This study investigated the analgesic and systemic effects of intramuscular (IM) versus epidural (EP) administration of tramadol as an adjunct to EP injection of lidocaine in cats. Six healthy, domestic, shorthair female cats underwent general anesthesia. A prospective, randomized, crossover trial was then conducted with each cat receiving the following 3 treatments: EP injection of 2% lidocaine [LEP; 3.

Effects of epidural nalbuphine on intraoperative isoflurane and postoperative analgesic requirements in dogs.

Purpose: To measure the change in the minimum alveolar concentration of isoflurane (EtISO) associated with epidural nalbuphine and the postoperative analgesic requirements in dogs after ovariohysterectomy.

Methods: Twenty four healthy female dogs were randomly assigned to receive saline or nalbuphine at 0.3 or 0.

Nondecalcified histologic study of bone response to titanium implants topographically modified by laser with and without hydroxyapatite coating.

The purpose of this study was nondecalcified histologic analysis of titanium implants modified by laser with and without hydroxyapatite. Implants with three modified surfaces were inserted into rabbit tibias: group 1, machined surface; group 2, irradiated (laser); and group 3, irradiated and hydroxyapatite coated (biomimetic method). The mean surface roughness (Ra) scores of groups 2 and 3 were higher than that of group 1.

Comparative study between fibrin glue and platelet rich plasma in dogs skin grafts.

Purpose: Compare fibrin glue (Tissucol(®)) and platelet-rich plasma in full-thickness mesh skin grafts in dogs.

Methods: Eighteen dogs were used, divided into two groups: fibrin glue (FG) and platelet-rich plasma (PRP). In all the animals, a full-thickness 3x3 cm mesh skin graft was implanted.

Efficacy of concurrent epidural administration of neostigmine and lidocaine for perineal analgesia in geldings.

Objective: To evaluate perineal analgesic effects of 3 doses of neostigmine coadministered epidurally with lidocaine to geldings.

Animals: 6 healthy geldings.

Procedures: A few days before each treatment, a catheter was inserted between the first and second coccygeal vertebrae via the caudal approach in each gelding; the catheter tip was threaded approximately 10 cm cranial into the midsacral region.

Scanning electron microscopy and microbiological evaluation of equine burn wound repair after platelet-rich plasma gel treatment.

Deep second-degree burns (DSDb) involve all epidermis layers, including the basal laminae. In general, DSDb heals with extensive areas of scarring. Platelet-rich plasma (PRP) is a source of growth factors, obtained by centrifugation and addition of thrombin and calcium, resulting in a gel.

Thoracic epidural analgesia via the lumbosacral approach using multiport catheters with a low concentration of bupivacaine and morphine in sheep.

Objective: To determine the analgesic and systemic effects of thoracic epidural administration of bupivacaine (BP) and morphine (MP) in conscious sheep.

Study Design: Randomized, crossover, experimental study.

Animals: Six healthy castrated sheep weighing between 40 and 50 kg.

Lumbosacral epidural magnesium prolongs ketamine analgesia in conscious sheep.

Purpose: To determine the analgesic, motor, sedation and systemic effects of lumbosacral epidural magnesium sulphate added to ketamine in the sheep.

Methods: Six healthy adult male mixed-breed sheep; weighing 43 ± 5 kg and aged 20-36 months. Each sheep underwent three treatments, at least 2 weeks apart, via epidural injection: (1) ketamine (KE; 2.

Evaluation of thoracic epidural analgesia induced by lidocaine, ketamine, or both administered via a lumbosacral approach in dogs.

Objective: To determine the analgesic and systemic effects of thoracic epidural administration of ketamine, lidocaine, or both in conscious dogs.

Animals: 6 adult mixed-breed dogs.

Procedures: Each dog received 2% lidocaine hydrochloride without epinephrine (3.

The efficacy and safety of levobupivacaine administered by lumbosacral epidural route in conscious sheep.

The aim of this study was to evaluate 3 doses of levobupivacaine (LB) epidurally administered in sheep. Six adult male 24-36 month-old sheep received levobupivacaine at 3 doses, LB05 (0.05 mg/kg), LB15 (0.

Segmental dorsolumbar epidural analgesia via the caudal approach using multiple port catheters with ketamine or lidocaine or in combination in cattle.

Objective: To determine the analgesic and systemic effects of epidural administration of ketamine, lidocaine or a combination of ketamine/lidocaine in standing cattle.

Study Design: Prospective, randomized, experimental trial.

Animals: Six healthy male cattle weighing between 335 and 373 kg.

Surface and biomechanical study of titanium implants modified by laser with and without hydroxyapatite coating, in rabbits.

Surface and biomechanical analysis of titanium implant surfaces modified by laser beam with and without hydroxyapatite. Titanium implants with 3 different surfaces were inserted into the tibias of 30 rabbits: group I (GI) machined surface (control group), group II irradiated with laser (GII), and group III irradiated with laser and hydroxyapatite coating applied-biomimetic method (GIII). Topographical analysis with scanning electron microscopy was made before surgery in the tibia.

Evaluation of two regional anesthetic methods on the front limb of dogs using hyperbaric bupivacaine.

Purpose: To evaluate the effects of bupivacaine 0.5 and 0.25% in intravenous regional anesthesia (IVRA) and brachial plexus block (BPB), respectively, on anesthesia, motor block and cardiovascular parameters in dogs.

Evaluation of segmental dorsolumbar epidural analgesia with ketamine hydrochloride administered by use of nonstyletted multiple-port catheters via the caudal approach in cattle.

Objective: To evaluate use of nonstyletted multiple-port catheters for epidural administration of ketamine hydrochloride via the caudal approach to induce analgesia of the paralumbar fossa (flank) in cattle.

Animals: 6 healthy bulls.

Procedures: 1 week before experiments began, a multiple-port catheter was inserted by use of a Tuohy needle in all cattle via the caudal approach (between the first and second coccygeal vertebrae); the tip was threaded approximately 48 cm cranial into the dorsolumbar region.

Effects of platelet-rich plasma gel on skin healing in surgical wound in horses.

Purpose: To establish a low-cost method to prepare platelet-rich plasma (PRP) and evaluates the potential of platelet derived factors to enhance wound healing in the surgical wounds in equine.

Methods: To obtain a PRP gel, calcium gluconate and autologous thrombin were added to platelet-rich plasma. For the tests six saddle horses were used and two surgical incisions were made in each animal.

Effects of caudal epidural ketamine and/or lidocaine on heifers during reproductive procedures: a preliminary study.

Six 20-24-month-old heifers received ketamine (KE), 2% lidocaine (Li), or ketamine and 2% lidocaine (KELI) into the first intercoccygeal (Co(1)-Co(2)) epidural space while standing. Heart rate, arterial blood pressure (systolic, diastolic, and mean), respiratory rate, rectal temperature, analgesia, sedation, and ataxia were determined before treatment and at predetermined intervals. Subjective scoring was used to assess pain and discomfort in reproductive manipulations.

Use of castor oil polyurethane in an alternative technique for medial patella surgical correction in dogs.

Purpose: Comparative morphologic study of utilization of castor oil polymer in dogs joints, as an alternative technique to autogenous graft, in surgical correction of medial patella luxation.

Methods: Twelve adult dogs, of both sexes, were randomly allocated to two different groups of six animals each. Group I (biopolymer) consisted of the deepening of the right femoral troclea, with the implantation of the biopolymer prothesis, and compared to group II (control) which consisted of the conventional trocleoplastia technique with wedged cut of the left femoral troclea.

Analysis of titanium surface irradiated with laser, with and without deposited of durapatite.

Purpose: The aim of this study was to analyse the surface of titanium implants using disc irradiated with lasers.

Methods: Titanium discs were irradiated with laser high insensitive (Nd-YAG), deposited durapatite and used thermal treatment. Sample received qualitative morphological analyse trough micrographics with many size in SEM (Scanning Electron Microscopy).

Morphology of autogenous bone graft and castor oil polyurethane in the infraorbital rim of rabbits: a comparative study.

Purpose: Morphological study comparing castor oil polyurethane and autogenous bone graft to repair bone defect in zygomatic bone of rabbits.

Methods: Twenty-four adult, male New Zealand rabbits were randomly distributed between two groups of twelve. Bone defects of 5mm in diameter were cut through the zygomatic bone and filled with polyurethane discs in the experimental group or autogenous bone harvested from the tibia in the control group.