Publications by authors named "Rafael Crabbe"

Background: Constipation is a prevalent gastrointestinal disorder. Patient dissatisfaction with prescribed medications is common, and there is need for alternative management strategies. Evidence shows that Bifidobacterium species may be beneficial in constipation.

View Article and Find Full Text PDF
Article Synopsis
  • Chronic constipation (CC) is a prevalent digestive disorder that poses a significant healthcare challenge, and while experts recommend increasing fiber intake, evidence for specific fibers like polydextrose is still needed.
  • A study involving 128 adults with CC tested daily doses of polydextrose (8 g or 12 g) against a placebo over 4 weeks to assess the effect on gut transit time and gastrointestinal symptoms.
  • Results indicated no significant changes in gut function or stool characteristics after 2 or 4 weeks; however, improvements were noted in specific rectal symptom scores after 2 weeks and some stool scores after 4 weeks, indicating more research is necessary to confirm longer-term benefits.
View Article and Find Full Text PDF

In vitro data suggest that alisporivir is a substrate and inhibitor of CYP3A4 and P-gp. Hence, the potential for drug-drug interactions when alisporivir is co-administered with CYP3A4 and/or P-gp inhibitors such as ketoconazole, azithromycin and CYP3A4 inducers such as rifampin were evaluated in three separate clinical studies. Co-administration with ketoconazole (a strong CYP3A4 inhibitor) increased the Cmax , AUC and terminal elimination half-life of alisporivir by approximately two-, eight- ,and threefold, respectively.

View Article and Find Full Text PDF