N-acetyl-l-cysteine exacerbates kidney dysfunction caused by a chronic high-sodium diet in renal ischemia and reperfusion rats.

Aims: To investigate the effect of long-term N-acetyl-l-cysteine (NAC) treatment in Wistar rats subjected to renal ischemia and reperfusion (IR) and a chronic high‑sodium diet (HSD).

Main Methods: Adult male Wistar rats received an HSD (8.0% NaCl) or a normal‑sodium diet (NSD; 1.