Publications by authors named "Rafael Barcelo"
Background & Aims: The relationship between acute-on-chronic liver failure (ACLF) and acute variceal bleeding (AVB) is poorly understood. Specifically, the prevalence and prognosis of ACLF in the context of AVB is unclear, while the role of transjugular intrahepatic portosystemic shunt (TIPS) in the management in patients with ACLF has not been described to date.
Methods: A multicenter, international, observational study was conducted in 2,138 patients from 34 centers between 2011 and 2015.
Article Synopsis
- - Patients with acute variceal bleeding (AVB) and severe liver dysfunction (Child-Pugh C score) are at a higher risk of treatment failure and death, leading to the consideration of preemptive transjugular intrahepatic portosystemic shunt (p-TIPS) to improve survival outcomes.
- - A study involving 671 high-risk patients revealed that p-TIPS significantly reduced mortality in Child-Pugh C patients compared to traditional treatment methods, while it showed low mortality rates in Child-Pugh B patients even without p-TIPS.
- - The findings suggest that p-TIPS should be prioritized for Child-Pugh C patients experiencing AVB, and it may also benefit some Child-Pugh B patients at
The humoral immune response plays an important role in the clearance of Giardia lamblia. However, our knowledge about the specific antigens of G. lamblia that induce a protective immune response is limited.
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