The association between caffeine consumption and objective sleep variables is dependent on ADORA2A c.1083T>C genotypes.

Objective: To verify the association between c.1083T>C polymorphism in the adenosine receptor A gene (ADORA2A) and objective sleep, as well as the correlation between caffeine consumption, sleep parameters, and electroencephalographic spectral power in a large, population-based sample from São Paulo, Brazil.

Methods: This study was conducted in participants of the São Paulo Epidemiologic Sleep Study (EPISONO), a large, population-based survey consisting of a representative sample of the inhabitants of the city from São Paulo, Brazil, according to sex, age (20-80 years), and socioeconomic status in the year 2007.