Publications by authors named "Raesham Mahmood"
Functional neuroimaging research suggests that the amygdala is implicated in the pathophysiology of major depressive disorder (MDD). This systematic review aimed to identify consistently reported amygdala activity and functional connectivity (FC) abnormalities in antidepressant-free participants with MDD as compared to healthy controls at baseline (i.e.
View Article and Find Full Text PDFArticle Synopsis
- Preliminary evidence suggests psychedelics could be effective for treating major depressive disorder (MDD) but research on their neural mechanisms is limited.
- A systematic review analyzed neuroimaging correlates of antidepressant responses to psychedelics, focusing on studies involving psilocybin, ayahuasca, and LSD, and found significant brain activity and connectivity changes linked to treatment outcomes.
- The review highlights the default mode and limbic networks as potential areas for future exploration and emphasizes the need for more extensive research to verify these initial findings, as they are based on a small number of datasets.