Arch Physiol Biochem
October 2016
Context: Fibrates, the ligands of peroxisome profileferator-activated receptor-α have been shown to have a renal protective action in diabetic nephropathy (DN).
Objective: This study aimed to elucidate the effect of fenofibrate on renal transforming growth factor-β1 (TGF-β1) and Smad3 in Streptozotocin (STZ)-induced DN.
Methods: Diabetes was induced in rats by a single intraperitoneal injection of streptozotocin (55 mg/kg).