The study aimed to test if using a patient’s CYP2D6 genotype to guide metoprolol dosing could lower the risk of developing postoperative atrial fibrillation (AF) after cardiac surgery.
The trial involved 73 cardiac surgery patients, who were categorized based on their CYP2D6 metabolizer status to inform medication dosing.
Results showed that 30% of the patients developed postoperative AF, and there was no significant evidence that adjusting metoprolol based on metabolizer status effectively reduced this risk.