[Quantitative analysis of repetitive sequences in human genomic DNA and detection of an elevated ribosomal repeat copy number in patients with schizophrenia (the results of molecular and cytogenetic analysis)].

A modified version of quantitating repetitive sequences in genomic DNA was developed to allow comparisons for numerous individual genomes and simultaneous analysis of several sequences in each DNA specimen. The relative genomic content of ribosomal repeats (rDNA) was estimated for 75 individuals, including 33 healthy donors (HD) and 42 schizophrenic patients (SP). The rDNA copy number in HD was 427 +/- 18 (mean SE) per diploid nucleus, ranging 250-600.

[Hemodynamics and rheologic properties of the blood in meningococcemia associated with meningitis and complicated by septic shock and intracranial hypertension].

Central hemodynamic parameters characterizing cardiac contractility and peripheral resistive vascular tone, as well as blood aggregation ability, its structural and dynamic viscosity have been assessed by dynamic (disease duration up to 15 days) and complex studies in 28 patients with septic shock of meningococcal etiology accompanied by signs of meningitis. All the patients revealed signs of intracranial hypertension caused by the onset of acute hydrocephaly or brain edema. It has been demonstrated that on entry all the patients were characterized by the combination of low cardiac output syndrome and second degree high or low blood viscosity.

[Characteristics of blood circulation disorders in meningococcal meningoencephalitis].

Studies of liquorologic, hemodynamic, electrophysiologic, and biochemical characteristics of the blood, carried out over the course of the disease in 110 patients with purulent meningoencephalitis of meningococcal etiology, complicated by development of high intracranial hypertension, have revealed a hypokinetic type of circulation, characterized by reduced heart performance and elevated afterload, in the majority of the examinees during the acute period of the disease. Among the causes contributing to the formation of the hypokinetic type are inflammatory and dystrophic changes in the myocardium, deterioration of the blood rheology (of the high blood viscosity syndrome type), and vasopressor effect of elevated intracranial pressure (Cushing's phenomenon) resultant from brain edema developing in the majority of patients. The findings evidence the leading role of intracranial pressure elevation in the origin of increased tone of resistive vessels and in the development of macro- and microcirculatory disorders in the acute phase of the disease.

[Acute rise of intracranial pressure--one of the causes of disorders of systemic circulation in meningococcal lesions of the central nervous system].

Tetrapolar chest rheography was used to study the central hemodynamics in 110 patients with meningococcal meningitides. Of these, in 86 patients, meningitis was combined with coccemia. The hyperkinetic type prevailed with a simultaneous decrease of the rate of the normo- and hyperkinetic types as compared with the distribution of the circulation types in healthy persons.

[Study of cardiac function in generalized meningococcal infection based on various biochemical indicators].

The complicated course of meningococcal infection is distinguished by a long-term increase in the level of aspartate transferase and creatine phosphokinase. There were three types of changes in the activity of creatine phosphokinase, while changes in the activity of aspartate transferase were not so diverse. Patients had isolated as well as combined increase in the activity of both these enzymes.

[Diagnosis of cardiac lesions in the generalized form of meningococcal infection].

Activity of the enzymes indicating heart affection in the acute period and in disease dynamics was increased in 97 patients with generalized forms of meningococcal infection. Signs of cytolysis, according to the data of enzymatic blood examination, were revealed to the utmost degree in patients with typical complications of meningococcal infection--brain edema, which persisted for 10 days of the disease. Herpetic infection joins twice as often in patients with brain edema and is accompanied by a pronounced cytolytic component in the myocardium and liver.

[Hemosorption in infectious pathology].

Hemosorption was used for the treatment of 152 patients with purulent meningitis, sepsis complicated by shock, virus hepatitis and leptospirosis. A favorable effect of hemosorption in infections was based on highly effective correction of microcirculatory disorders as a result of the removal of high molecular substances of microbic and endogenous origin.

[Enzymologic diagnosis of cerebral lesions in generalized forms of meningococcal infection in the acute period].

Cerebrospinal fluid was tested for several enzymes (CPK, AST, GGTP, BP, BG, AK) in 97 patients with generalized meningococcal infection with prevalent CNS affliction. Marked changes were detected even in the absence of clinical signs of cerebral lesion that was typical only of meningococcemia. Nevertheless, most pronounced changes were observed in a group of patients with cerebral edema and swelling.

[The enzyme diagnosis of liver involvement in meningococcal infection].

A complex of blood enzymes (AST, ALT, AP, GTT) was studied in 84 patients with generalized forms of MI. The study showed that signs of liver involvement were noted in 15.4% of the patients on the 1st day of disease.

[Role of hemosorption in the therapy of infectious toxic shock and the multiple-organ failure syndrome in a fulminating form of meningococcemia].

Hemoperfusion was applied to the treatment of 20 patients with fulminant meningococcemia complicated by the infectious-toxic shock, stage III, and the polyorgan insufficiency syndrome. Ten patients recovered while the remaining 10 died mainly because of irreversible lesions of the vitally important organs: kidneys, adrenals, heart and brain. In the deceased patients, the prehospital stage had lasted two times longer than in the convalescents.

[Changes in the rheologic properties of blood in septic shock].

Results of examination of rheological properties of blood in 62 patients with septic shock of peritoneal etiology are presented. The control group included 50 patients with diffuse peritonitis without manifestations of septic shock. In patients with favourable outcomes of the disease septic shock was accompanied by the development of the high blood viscosity syndrome of the IInd degree or low blood viscosity syndrome of the Ist degree when microcirculatory and thrombohemorrhagic complications were of a reversible character.

[Rheologic disorders in myocardial infarct complicated by acute left ventricular failure].

Thirty-six patients with acute myocardial infarction aggravated by acute left ventricular failure (pulmonary edema, cardiogenic shock) were studied for their blood rheologic properties. The impairments of the blood rheologic properties were classified as Stage I and II syndromes of high and low blood viscosity and were characterized by a phasic nature of their course. The rheologic disorders associated with pulmonary edema and reversed cardiogenic shock were decompensated (Stage II syndrome of high blood viscosity--Stage I syndrome of low blood viscosity), but reversible following intensive rheologic therapy.

[Clinical pathophysiology and intensive therapy of diffuse peritonitis].

The work describes the results of an investigation of pathophysiological shifts and methods for their correction used in 204 patients with diffuse peritonitis. It is concerned with problems of diagnosis and therapy of protein, water-electrolyte disorders, acute respiratory insufficiency, "shock lung". Pharmacodynamic and pharmacokinetic properties of cephalosporins injected intravenously and intra-orally were studied.