[The diagnostic significance of lipoprotein-X].

Lipoproteid-X was revealed at the onset of the disease in 59.6% of patients with acute viral hepatitis with prevalence of the cholestasis syndrome and cytolysis. Lipoproteid-X may be revealed in moderate activity of alkaline phosphatase.

[Two forms of alkaline phosphatase in blood serum in liver diseases].

A fraction whose electrophoretic mobility in polyacrylamide gel corresponded to the liver isoenzyme was produced due to trypsin hydrolysis of the high-molecular alkaline phosphatase of blood serum of patients suffering from liver diseases and of liver homogenates. In the presence of positively and negatively charged micelles of detergents the electrophoretical mobility of high-molecular alkaline phosphatase in agarose changed essentially as compared to that in the presence of the noncharged detergent micelles. Similar changes in mobility were not observed for the liver isoenzyme.

[Enzyme activity in the regeneration process after partial hepatectomy of normal liver and that injured with deoxycholic acid].

After partial hepatoectomy of the rat normal liver a maximum three-fold increase in the activity of alkaline phosphatase is observed in the blood serum, on the second-third day, and by the 14th day becomes almost normal; the activity of adenosine desaminase, AMP-aminohydrolase and 5'-nucleotidase becomes 30-60% as high for one-two days. The activity of the alkaline phosphatase in the liver becomes four times as high and reaches normalcy by the sixth day. The activity of adenosine desaminase and AMP-aminohydrolase increases to a less extent for a fortnight.

[Two forms of alkaline phosphatase and 5'-nucleotidase in the serum of persons with jaundice of different origin].

Distribution of the alkaline phosphatase and 5'-nucleotidase activity was studied in blood serum by means of gel filtration through Sephadex G-200 with jaundices of different origin. Both enzymes have two forms differing in the molecular weight, 5'-nucleotidase presenting mainly a high-molecular form in contrast to alkaline phosphatase. This form activity for both enzymes is higher with obturative jaundices as compared to liver cirrhosis and virus hepatitis.