Publications by authors named "Radu-Cristian Cimpeanu"
Background/objectives: The prognostic nutritional index (PNI) and Glasgow Prognostic Score (GPS) are associated with patients' nutritional and immune statuses. One important factor in the pathophysiology of type 2 diabetes mellitus (T2DM) is inflammation. Being present in insulin-target tissues, chronic tissue inflammation has become recognized as a crucial aspect of obesity and type 2 diabetes.
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- A retrospective study was conducted on 55 patients diagnosed with gastroenteropancreatic neuroendocrine tumors (GEP-NETs) at The Clinical Emergency County Hospital Craiova, focusing on epidemiological and clinical aspects.
- The majority of patients were older adults, with a mean age of 66.4 years, and GEP-NETs were most commonly found in the colon, specifically the ascending colon.
- Notable findings included a higher prevalence of arterial hypertension in patients with colon neuroendocrine tumors (C-NET) and an overall increase in GEP-NET cases in recent years.
Article Synopsis
- The study examines the relationship between Type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD) in Romanian patients, highlighting the effectiveness of antidiabetic drugs like GLP-1 Ras and SGLT-2 inhibitors.
- Conducted with 405 T2DM patients, the study found that while many achieved satisfactory blood sugar levels, they struggled to meet overall health targets including blood pressure and cholesterol management.
- Results indicated a high prevalence of comorbidities, particularly hypertension and obesity, and revealed a low usage of advanced treatments like GLP-1 Ras and SGLT-2 inhibitors, along with statins.
Correlation between Neurotransmitters (Dopamine, Epinephrine, Norepinephrine, Serotonin), Prognostic Nutritional Index, Glasgow Prognostic Score, Systemic Inflammatory Response Markers, and TNM Staging in a Cohort of Colorectal Neuroendocrine Tumor Patients.
Int J Mol Sci
June 2024
Article Synopsis
- Neuroendocrine tumors (CR-NETs) are rare in the gastrointestinal tract but can arise in various epithelial organs, prompting research into the roles of serum dopamine, serotonin, norepinephrine, and epinephrine in these tumors.
- The study analyzed 25 CR-NET patients and 60 colorectal cancer patients, finding that CR-NET patients had higher serum dopamine levels, especially in early TNM stages, suggesting dopamine's potential as a prognostic marker.
- Additionally, connections between serum dopamine, nutritional status (measured by the Prognostic Nutritional Index), and systemic inflammation indicate that these markers may assist in evaluating CR-NET patients' health and guiding treatment strategies.
The tuberous sclerosis complex (TSC) is highly variable as far as its clinical presentation is concerned. For the implementation of appropriate medical surveillance and treatment, an accurate diagnosis is compulsory. TSC may affect the heart, skin, kidneys, central nervous system (epileptic seizures and nodular intracranial tumors-tubers), bones, eyes, lungs, blood vessels and the gastrointestinal tract.
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